{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:01:14Z","timestamp":1784372474338,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21405165"],"award-info":[{"award-number":["21405165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21675164"],"award-info":[{"award-number":["21675164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21650110454"],"award-info":[{"award-number":["21650110454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Graphene oxides (GO) are attracting much attention in the diagnosis and therapy of the subcutaneous tumor as a novel biomaterial, but its diagnosis to tissue dysfunction is yet to be found. Here, a novel application of GO for diagnosis of renal dysfunction via contrast\u2010enhanced computed tomography (CT) is proposed. In order to serve as contrast\u2010enhanced agent, Ag nanoparticles (AgNPs) are composited on the surface of GO to promote its X\u2010ray absorption, and then simvastatin is coinjected for eliminating in vivo toxicity induced by AgNPs. It is found that GO\/AgNPs can enhance the imaging of CT into the lung, liver, and kidney of mice for a long circulation time (\u224824 h) and a safety profile in vivo in the presence of simvastatin. Interestingly, the lower dose of GO\/AgNPs (\u22480.5 mg per kg bw) shows an excellent performance for CT imaging of renal perfusion, and visually exhibits the right renal dysfunction in model mice. Hence, this work suggests that graphene nanoparticles will play a vital role for the future medical translational development including drug carrier, biosensing, and disease therapy.<\/jats:p>","DOI":"10.1002\/adhm.201700413","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T16:13:20Z","timestamp":1496247200000},"source":"Crossref","is-referenced-by-count":30,"title":["Graphene Oxide\/Ag Nanoparticles Cooperated with Simvastatin as a High Sensitive X\u2010Ray Computed Tomography Imaging Agent for Diagnosis of Renal Dysfunctions"],"prefix":"10.1002","volume":"6","author":[{"given":"Zhan","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Medical College of Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianli","family":"Liu","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Applied Electromagnetic Engineering School of Electrical and Electronic Engineering Huazhong University of Science and Technology  Wuhan 430000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Wang","sequence":"additional","affiliation":[{"name":"Radiochemistry Laboratory Lanzhou University  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Chand","family":"Ali","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangsuo","family":"Wu","sequence":"additional","affiliation":[{"name":"Radiochemistry Laboratory Lanzhou University  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongdeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical Physics Chinese Academy of Sciences  Lanzhou 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1571"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.055"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.042"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.09.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.12.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201106102"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201100191"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.38"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.08.036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201400329"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.05.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600647"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.03.072"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2016.11.097"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.12.028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b00521"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.12.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.031"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200489"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1024303"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/am.2013.7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.042"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.11.055"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.027"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-016-1264-x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507070"},{"key":"e_1_2_7_27_1","unstructured":"Statins: Widely used drugs may protect people from air pollution http:\/\/www.environmentalhealthnews.org\/ehs\/news\/2014\/nov\/statins\u2010and\u2010air\u2010pollution(accessed: April 2017)."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1006368"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200901048"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900726"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11125f"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA09422K"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-010-0185-y"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep05341"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-7-473"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10258"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201417"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.021"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.015"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR01444A"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201203700"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/am200428v"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.045"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.60"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1024303"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.243"},{"key":"e_1_2_7_47_1","first-page":"101","volume":"22","author":"Fukuda H.","year":"2007","journal-title":"Nephrol., Dial., Transplant."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2781-z"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.416"},{"key":"e_1_2_7_50_1","first-page":"S307","volume":"38","author":"Al\u2010Mardoof A. O.","year":"2011","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.01.001"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1024303"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b00539"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201001068"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn1006368"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.06.043"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tx50060h"},{"key":"e_1_2_7_58_1","first-page":"245","volume":"59","author":"Gonzalez\u2010Avila G.","year":"1988","journal-title":"Lab. Invest."},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V122317"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201700413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201700413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201700413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201700413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:04:57Z","timestamp":1759781097000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201700413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":59,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1002\/adhm.201700413"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201700413","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]},"article-number":"1700413"}}