{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:07:16Z","timestamp":1791976036303,"version":"4.4.0"},"reference-count":440,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1605225"],"award-info":[{"award-number":["U1605225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570974"],"award-info":[{"award-number":["31570974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470927"],"award-info":[{"award-number":["31470927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99CA201603"],"award-info":[{"award-number":["K99CA201603"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003815","name":"Huaqiao University","doi-asserted-by":"publisher","award":["16BS803"],"award-info":[{"award-number":["16BS803"]}],"id":[{"id":"10.13039\/501100003815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high\u2010pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC\u2010CO<jats:sub>2<\/jats:sub>) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio\u2010imaging, and other biomedical applications. We finally summarize with perspectives.<\/jats:p>","DOI":"10.1002\/adhm.201700433","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T04:34:50Z","timestamp":1501216490000},"source":"Crossref","is-referenced-by-count":256,"title":["Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications"],"prefix":"10.1002","volume":"6","author":[{"given":"Ranjith Kumar","family":"Kankala","sequence":"first","affiliation":[{"name":"College of Chemical Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Institute of Biomaterials and Tissue Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Fujian Provincial Key Laboratory of Biochemical Technology  Xiamen 361021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-0808","authenticated-orcid":false,"given":"Yu Shrike","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Institute of Biomaterials and Tissue Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Fujian Provincial Key Laboratory of Biochemical Technology  Xiamen 361021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science and Institute of Biotechnology National Dong Hwa University  Hualien 97401 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Zheng","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Institute of Biomaterials and Tissue Engineering Huaqiao University  Xiamen 361021 P. R. China"},{"name":"Fujian Provincial Key Laboratory of Biochemical Technology  Xiamen 361021 P. R. China"},{"name":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_10_1_1","first-page":"173","volume":"18","author":"Kompella U. B.","year":"2001","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(00)00332-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.05.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218494"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S596"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9337-6"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(05)71036-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S19021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/195727"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr940351u"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-073009-100847"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2004.10.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.08.015"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201403036"},{"key":"e_1_2_10_9_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2015.07.044"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB03146C"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128245"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.07.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.110"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cep.2014.10.009"},{"key":"e_1_2_10_13_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.07.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.03.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.04.032"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(03)00011-1"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2004.02.007"},{"key":"e_1_2_10_16_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.02.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.12.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie301683s"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR07161E"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.02.033"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4596(03)00079-3"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/b207052a"},{"key":"e_1_2_10_20_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-577X(01)00472-4"},{"key":"e_1_2_10_20_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2005.08.003"},{"key":"e_1_2_10_20_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.09.001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cossms.2003.12.005"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp0212747"},{"key":"e_1_2_10_21_3","doi-asserted-by":"publisher","DOI":"10.1021\/ie010760y"},{"key":"e_1_2_10_21_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(01)00124-3"},{"key":"e_1_2_10_22_1","volume-title":"Perry's Chemical Engineers' Handbook","author":"Perry R. H.","year":"1997"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.02.002"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.02.003"},{"key":"e_1_2_10_23_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.05.002"},{"key":"e_1_2_10_23_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2013.10.003"},{"key":"e_1_2_10_23_5","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2.4.747"},{"key":"e_1_2_10_23_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.03.017"},{"key":"e_1_2_10_23_7","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2014.07.019"},{"key":"e_1_2_10_23_8","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.06.019"},{"key":"e_1_2_10_23_9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.10.011"},{"key":"e_1_2_10_23_10","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150416100201"},{"key":"e_1_2_10_23_11","doi-asserted-by":"publisher","DOI":"10.2174\/156720112800389052"},{"key":"e_1_2_10_23_12","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2012.652614"},{"key":"e_1_2_10_23_13","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.125"},{"key":"e_1_2_10_23_14","doi-asserted-by":"publisher","DOI":"10.1177\/0883911509105796"},{"key":"e_1_2_10_23_15","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.891014"},{"key":"e_1_2_10_23_16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.07.010"},{"key":"e_1_2_10_23_17","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00100A"},{"key":"e_1_2_10_23_18","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2014.12.028"},{"key":"e_1_2_10_23_19","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.04.010"},{"key":"e_1_2_10_23_20","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2012.0361"},{"key":"e_1_2_10_23_21","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.01.030"},{"key":"e_1_2_10_23_22","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.030"},{"key":"e_1_2_10_23_23","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.03.023"},{"key":"e_1_2_10_23_24","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.11.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.08.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.03.027"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00649-X"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.09.071"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260410308"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(96)01508-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie020205b"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b04137"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma5101841"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S32662"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.05.009"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc5005922"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl4017072"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie010943k"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2014.01.054"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00063-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(02)00248-6"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2012.05.038"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie050417j"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2016.01.033"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2012.04.010"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2015.09.035"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21920"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00577-X"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022684911383"},{"key":"e_1_2_10_42_3","volume":"5","author":"Chen A.\u2010Z.","year":"2012","journal-title":"Materials"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.02.019"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011949805156"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.04.009"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(02)00188-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.12.002"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp0218645"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400487f"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.051"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.11.025"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cep.2007.04.011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017541705569"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-1992-0514.ch019"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-014-4680-8"},{"key":"e_1_2_10_57_1","volume":"14","author":"Zhao Z.","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/ie301907f"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-006-9192-0"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-008-9152-7"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2006.03.018"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-5910(00)00257-6"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.200600221"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-015-5447-x"},{"key":"e_1_2_10_61_3","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S85999"},{"key":"e_1_2_10_61_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.049"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.11.005"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(01)00088-2"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.01.002"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00071-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00905-X"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/bp9600492"},{"key":"e_1_2_10_65_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.003"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.05.013"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0403-z"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.10.003"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie201294u"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2005.09.005"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.11.006"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500758s"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(93)90166-3"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja003008h"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.06.009"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.04.020"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.10.015"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.04.053"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2014.07.029"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00715A"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.016"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.143"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00009-7"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.12201"},{"key":"e_1_2_10_81_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.02.030"},{"key":"e_1_2_10_81_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(01)00109-7"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.05.004"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(02)00186-9"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.01.002"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.06.008"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3173-8"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0248-x"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690480419"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie030199z"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690460418"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.08.018"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.12.048"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma6083571"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687860600945552"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/js980237h"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690480207"},{"key":"e_1_2_10_93_2","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1002\/jps.10497","volume":"92","author":"Todo H.","journal-title":"J. Pharm. Sci."},{"key":"e_1_2_10_93_3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/js950482q","volume":"85","author":"Winters M. A.","journal-title":"J. Pharm. Sci."},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00108-1"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(99)00079-2"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00152-4"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20555"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/12\/5\/303"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.10.031"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.03.001"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22346"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2014.04.002"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.02.009"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.01.013"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.05.010"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018955410414"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/583952"},{"key":"e_1_2_10_103_3","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-9094-7"},{"key":"e_1_2_10_103_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00078-9"},{"key":"e_1_2_10_103_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2004.06.007"},{"key":"e_1_2_10_103_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2008.01.003"},{"key":"e_1_2_10_103_7","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9227-7"},{"key":"e_1_2_10_103_8","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20702"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.062"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.02.022"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA16957C"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-8-386"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.07.010"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.09.007"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.11.026"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(00)00076-0"},{"key":"e_1_2_10_111_1","first-page":"365","volume":"8","author":"Karn P. R.","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.04.018"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.57.613"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.02.005"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.09.022"},{"key":"e_1_2_10_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.02.005"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(94)90155-4"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.00493.x"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600680550"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00167"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(00)00045-0"},{"key":"e_1_2_10_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2004.02.017"},{"key":"e_1_2_10_120_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00237-3"},{"key":"e_1_2_10_120_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00024-3"},{"key":"e_1_2_10_120_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2004.02.001"},{"key":"e_1_2_10_120_6","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-5910(99)00062-5"},{"key":"e_1_2_10_120_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00261-2"},{"key":"e_1_2_10_121_1","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/jps.10193","volume":"91","author":"Snavely W. K.","journal-title":"J. Pharm. Sci."},{"key":"e_1_2_10_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.03.010"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0290(20010105)72:1<12::AID-BIT2>3.0.CO;2-Z"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.10.040"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.03.027"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.60.334"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.239.4838.387"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19990205)62:3<247::AID-BIT1>3.0.CO;2-S"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.03.001"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2007.06.008"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie0004904"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.1113"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10285"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1504"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.01.063"},{"key":"e_1_2_10_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.10.053"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.08.033"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.027"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H135"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.4.1.19"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9306-4"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2008.10.004"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.05.006"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.08.014"},{"key":"e_1_2_10_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.07.007"},{"key":"e_1_2_10_142_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.10.002"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.02.007"},{"key":"e_1_2_10_143_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.01.016"},{"key":"e_1_2_10_143_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.02.001"},{"key":"e_1_2_10_143_4","doi-asserted-by":"publisher","DOI":"10.2174\/156720108783954851"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.123"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-5130-z"},{"key":"e_1_2_10_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.06.010"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1995.1.151"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1039\/b814285h"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-014-0026-7"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200290003"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm700891b"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.02.020"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/10\/3\/035015"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00138-8"},{"key":"e_1_2_10_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.03.030"},{"key":"e_1_2_10_153_3","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S129526"},{"key":"e_1_2_10_154_1","volume":"7","author":"Song H.\u2010F.","year":"2014","journal-title":"Materials"},{"key":"e_1_2_10_154_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma7042459"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.040"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.04.018"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2011.12.002"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.07.021"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S129526"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.05.004"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.07.042"},{"key":"e_1_2_10_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.03.028"},{"key":"e_1_2_10_161_3","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v29.i1.10"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.14607"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.01.047"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4095(200110)13:19<1459::AID-ADMA1459>3.0.CO;2-K"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00268-0"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1101-1029"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2016.10.010"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.023"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1039\/b507722m"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.029"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.07.015"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.05.017"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3gc41060a"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00138-8"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.03.026"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2015.08.024"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.01.051"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2004.10.1037"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1390"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat983"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/0032-5910(95)03021-X"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/0032-5910(91)80205-W"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.11.012"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10344"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fjmd.2011.03.004"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.03.017"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2015.11.013"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.01.007"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10209"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13056454"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3633-9"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.06.022"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1021\/je400484u"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2009.07.012"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.09.017"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.12.013"},{"key":"e_1_2_10_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.02.013"},{"key":"e_1_2_10_196_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.08.002"},{"key":"e_1_2_10_196_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2009.06.034"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.09.008"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.07.003"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.01.001"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.04.010"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie050654m"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2005.09.042"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie901616n"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2012.655329"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11814-008-0098-y"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13045060"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.07.011"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.07.006"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.06.005"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.01.009"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2011.07.036"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00711-6"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.57.12.0003"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/ceat.200800114"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20850"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2007.02.029"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.06.020"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.11.016"},{"key":"e_1_2_10_218_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S80434"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.04.021"},{"key":"e_1_2_10_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2015.12.151"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnoncrysol.2004.06.031"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S88375"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1191-4"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.05.017"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.12.049"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.04.041"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.08.026"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1080\/01932691.2011.599231"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.08.005"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.11.031"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-8635-4"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-200047368"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.10.039"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.07.014"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.10.045"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.06.038"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.06.010"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/215\/1\/012087"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.07.027"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(20000220)67:4<457::AID-BIT9>3.0.CO;2-K"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.838581"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2008.10.085"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.08.031"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1021\/la047934b"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.10.015"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2013.807457"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1080\/02726359708906772"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0187-2"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.08.023"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2009.05.002"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23361"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie901913x"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2013.11.019"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2011.10.025"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2009.05.010"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-5910(02)00045-1"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.36492"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2016.02.008"},{"key":"e_1_2_10_258_1","first-page":"4269","volume":"9","author":"Ha E. S.","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.03.004"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.09.035"},{"key":"e_1_2_10_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.02.018"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4926-1"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2012.01.023"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2005.11.005"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.11.012"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720107781023901"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(02)00267-X"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.11.012"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2010.531735"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1ra00070e"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2008.02.031"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2014.07.007"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1021\/la062739d"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21598"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2013.769570"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.768630"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2009.02.004"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22647"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2009.09.003"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB21099E"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22147"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-015-0312-2"},{"key":"e_1_2_10_282_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S92665"},{"key":"e_1_2_10_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2003.09.005"},{"key":"e_1_2_10_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrysgro.2011.06.059"},{"key":"e_1_2_10_285_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639040500388037"},{"key":"e_1_2_10_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2015.02.031"},{"key":"e_1_2_10_287_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.11.005"},{"key":"e_1_2_10_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnoncrysol.2015.11.011"},{"key":"e_1_2_10_289_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24377"},{"key":"e_1_2_10_290_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2015.05.087"},{"key":"e_1_2_10_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.10.032"},{"key":"e_1_2_10_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2005.05.011"},{"key":"e_1_2_10_293_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-006-9175-1"},{"key":"e_1_2_10_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2006.02.009"},{"key":"e_1_2_10_294_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9177-0"},{"key":"e_1_2_10_295_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(03)00358-6"},{"key":"e_1_2_10_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.01.010"},{"key":"e_1_2_10_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.09.006"},{"key":"e_1_2_10_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.06.011"},{"key":"e_1_2_10_299_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023084617964"},{"key":"e_1_2_10_300_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj070116"},{"key":"e_1_2_10_300_2","first-page":"378","volume":"7","author":"Barillaro V.","year":"2004","journal-title":"J. Pharm. Pharm. Sci."},{"key":"e_1_2_10_301_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023028815180"},{"key":"e_1_2_10_302_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018955410414"},{"key":"e_1_2_10_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2012.07.001"},{"key":"e_1_2_10_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.07.005"},{"key":"e_1_2_10_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2006.11.013"},{"key":"e_1_2_10_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2014.03.099"},{"key":"e_1_2_10_307_1","first-page":"3791","volume":"9","author":"Karn P. R.","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"e_1_2_10_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.06.014"},{"key":"e_1_2_10_309_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21434"},{"key":"e_1_2_10_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.026"},{"key":"e_1_2_10_311_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.02.051"},{"key":"e_1_2_10_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2010.05.013"},{"key":"e_1_2_10_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(03)00034-2"},{"key":"e_1_2_10_314_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S12415"},{"key":"e_1_2_10_315_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.05.029"},{"key":"e_1_2_10_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.11.008"},{"key":"e_1_2_10_317_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00127-1"},{"key":"e_1_2_10_318_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.11.006"},{"key":"e_1_2_10_318_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020477204512"},{"key":"e_1_2_10_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2005.10.004"},{"key":"e_1_2_10_320_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00870-5"},{"key":"e_1_2_10_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2007.05.007"},{"key":"e_1_2_10_321_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.01.019"},{"key":"e_1_2_10_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2007.04.009"},{"key":"e_1_2_10_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.07.008"},{"key":"e_1_2_10_324_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma6083571"},{"key":"e_1_2_10_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.10.002"},{"key":"e_1_2_10_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2007.05.026"},{"key":"e_1_2_10_327_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.1107"},{"key":"e_1_2_10_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.12.024"},{"key":"e_1_2_10_329_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8446(02)00162-6"},{"key":"e_1_2_10_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.12.047"},{"key":"e_1_2_10_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-8502(03)00022-3"},{"key":"e_1_2_10_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.02.030"},{"key":"e_1_2_10_332_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2009.07.016"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201700433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201700433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:54:22Z","timestamp":1759773262000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201700433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":440,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/adhm.201700433"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201700433","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]},"article-number":"1700433"}}