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Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP\u2010based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4\u2010ethylenedioxythiophene):polystyrene sulfonate (PEDOT\u2010MeOH:PSS) and (3\u2010aminopropyl)triethoxysilane is designed. The resultant PEDOT\u2010MeOH:PSS\u2013AgNP composite presents a consistent coating of covalently linked AgNPs, as shown by scanning electron microscopy and surface plasmon resonance analysis. The efficacy of the coatings, with and without electrical addressing, is then tested against <jats:italic>Staphylococcus aureus<\/jats:italic>, a major colonizer of medical implants. Using custom\u2010designed culturing devices, a nearly complete prevention of biofilm growth is obtained in AgNP composite devices addressed with a square wave voltage input. It is concluded that this electroenhancement of the bactericidal effect of the coupled AgNPs offers a novel, efficient solution against biofilm colonization of medical implants.<\/jats:p>","DOI":"10.1002\/adhm.201700435","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T03:02:39Z","timestamp":1502679759000},"source":"Crossref","is-referenced-by-count":36,"title":["Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents <i>Staphylococcus aureus<\/i> Biofilm Formation"],"prefix":"10.1002","volume":"6","author":[{"given":"Salvador","family":"Gomez\u2010Carretero","sequence":"first","affiliation":[{"name":"Swedish Medical Nanoscience Center Department of Neuroscience Karolinska Institutet  171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Nybom","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet  171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Richter\u2010Dahlfors","sequence":"additional","affiliation":[{"name":"Swedish Medical Nanoscience Center Department of Neuroscience Karolinska Institutet  171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_5_1_1","first-page":"615","volume":"7","author":"Bottros M. 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