{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:58:45Z","timestamp":1781812725957,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015M3A9E2029265"],"award-info":[{"award-number":["2015M3A9E2029265"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["#2V05420"],"award-info":[{"award-number":["#2V05420"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>A noninvasive quantitative assay that is capable of identifying prostate cancer biomarkers in untreated urine is an attractive diagnosis tool, but this method is subject to various obstacles. Difficulties presented by untreated urine include varying salt concentrations, and pH levels that may be different even though they are from the same patient. Untreated urine also presents interference from other biomolecules and possesses a fewer number of cancer biomarkers than can be found in serum. As a result, urine preconditioning processes and digital rectal examination (DRE) to increase biomarker secretion are mandatory in current urine assays. To address these challenges, an ion\u2010responsive urine sensor (IRUS) that measures differential electrical signals is proposed as a self\u2010normalized detection method. The proposed IRUS is based on a FET biosensor with a disposable sensing gate and has the capability to detect the prostate cancer antigen ANXA3 in untreated patient urine. The IRUS can detect ANXA3 at &lt;1 fg mL<jats:sup>\u22121<\/jats:sup> with high reliability. In addition, it is found that ANXA3 levels in urine show clinically significant correlation with real tumor volumes. This paper provides a guideline in developing a clinically ready accurate noninvasive platform, which is capable of predicting prostate cancer using untreated urine without DRE.<\/jats:p>","DOI":"10.1002\/adhm.201700449","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T10:02:57Z","timestamp":1499940177000},"source":"Crossref","is-referenced-by-count":25,"title":["Self\u2010Normalized Detection of ANXA3 from Untreated Urine of Prostate Cancer Patients without Digital Rectal Examination"],"prefix":"10.1002","volume":"6","author":[{"given":"Minhong","family":"Jeun","sequence":"first","affiliation":[{"name":"Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwook","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 Republic of Korea"},{"name":"Department of Biomedical Engineering Korea University of Science and Technology (UST)  217 Gajeong\u2010ro Yuseong\u2010gu Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewon","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 Republic of Korea"},{"name":"Department of Biomedical Engineering Korea University of Science and Technology (UST)  217 Gajeong\u2010ro Yuseong\u2010gu Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Center University of Ulsan College of Medicine  88 Olympic\u2010ro 43\u2010gil Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Gab","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Center University of Ulsan College of Medicine  88 Olympic\u2010ro 43\u2010gil Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Center University of Ulsan College of Medicine  88 Olympic\u2010ro 43\u2010gil Songpa\u2010gu Seoul 05505 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-844X","authenticated-orcid":false,"given":"Kwan Hyi","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST)  5 Hwarang\u2010ro 14\u2010gil Seongbuk\u2010gu Seoul 02792 Republic of Korea"},{"name":"Department of Biomedical Engineering Korea University of Science and Technology (UST)  217 Gajeong\u2010ro Yuseong\u2010gu Daejeon 34113 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2011.01.art2"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07584"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.10.004"},{"key":"e_1_2_7_4_1","first-page":"6555","volume":"10","author":"Kang B. 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