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Neurological disorders represent a significant proportion of diseases burden; however, the complexity of the brain physiology makes it challenging to model its diseases. Simple in vitro models have been very useful for precise measurements in controled conditions. However, existing models are limited in their ability to replicate complex interactions between various cells in the brain. Studying human brain requires sophisticated models to reconstitute the tangled architecture and functions of brain cells. Recently, advances in the development of three\u2010dimensional (3D) brain cell culture models have begun to recapitulate various aspects of the human brain physiology in vitro and replicate basic disease processes of Alzheimer's disease, amyotrophic lateral sclerosis, and microcephaly. In this review, we discuss the progress, advantages, limitations, and future directions of 3D cell culture systems for modeling the human brain development and diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.201700723","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T06:12:54Z","timestamp":1503900774000},"source":"Crossref","is-referenced-by-count":100,"title":["Three\u2010Dimensional Models of the Human Brain Development and Diseases"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-6190","authenticated-orcid":false,"given":"Mehdi","family":"Jorfi","sequence":"first","affiliation":[{"name":"Center for Engineering in Medicine Massachusetts General Hospital Harvard Medical School  Charlestown Massachusetts 02129 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"D'Avanzo","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit 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