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Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad\u2010spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure\u2013activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad\u2010spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer\u2010based antivirals and represent promising candidates for further development as preventive microbicides.<\/jats:p>","DOI":"10.1002\/adhm.201700748","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T12:15:06Z","timestamp":1506341706000},"source":"Crossref","is-referenced-by-count":56,"title":["Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses"],"prefix":"10.1002","volume":"6","author":[{"given":"Franziska","family":"Schandock","sequence":"first","affiliation":[{"name":"Institute of Molecular Virology Ulm University Medical Center  Meyerhofstrasse 1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Frich","family":"Riber","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"R\u00f6cker","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology Ulm University Medical Center  Meyerhofstrasse 1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology Ulm University Medical Center  Meyerhofstrasse 1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirja","family":"Harms","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology Ulm University Medical Center  Meyerhofstrasse 1 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Gajda","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Zuwala","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital  Aarhus 8000 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H. 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