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However, achieving the ultimate purpose of using biomolecule\u2010responsive hydrogels in preclinical and clinical areas is still at the very early stage and calls for more novel designing concepts and advance ideas. On the way toward the real\/clinical application of biomolecule\u2010responsive hydrogels, plenty of factors should be extensively studied and examined under both in vitro and in vivo conditions. For example, biocompatibility, biointegration, and toxicity of biomolecule\u2010responsive hydrogels should be carefully evaluated. From the living body's point of view, biocompatibility is seriously depended on the interactions at the tissue\/polymer interface. These interactions are influenced by physical nature, chemical structure, surface properties, and degradation of the materials. 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