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More recently, soy protein has received attention for a variety of its potential health benefits, including enhanced skin regeneration. It has been reported that soy protein possesses bioactive molecules similar to extracellular matrix (ECM) proteins and estrogen. In wound healing, oral and topical soy has been heralded as a safe and cost\u2010effective alternative to animal protein and endogenous estrogen. However, engineering soy protein\u2010based fibrous dressings, while recapitulating ECM microenvironment and maintaining a moist environment, remains a challenge. Here, the development of an entirely plant\u2010based nanofibrous dressing comprised of cellulose acetate (CA) and soy protein hydrolysate (SPH) using rotary jet spinning is described. The spun nanofibers successfully mimic physicochemical properties of the native skin ECM and exhibit a high water retaining capability. In vitro, CA\/SPH nanofibers promote fibroblast proliferation, migration, infiltration, and integrin \u03b21 expression. In vivo, CA\/SPH scaffolds accelerate re\u2010epithelialization and epidermal thinning as well as reduce scar formation and collagen anisotropy in a similar fashion to other fibrous scaffolds, but without the use of animal proteins or synthetic polymers. These results affirm the potential of CA\/SPH nanofibers as a novel wound dressing.<\/jats:p>","DOI":"10.1002\/adhm.201701175","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T07:13:32Z","timestamp":1516691612000},"source":"Crossref","is-referenced-by-count":208,"title":["Soy Protein\/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing"],"prefix":"10.1002","volume":"7","author":[{"given":"Seungkuk","family":"Ahn","sequence":"first","affiliation":[{"name":"Disease Biophysics Group Wyss Institute for Biologically Inspired Engineering Harvard University  29 Oxford St. Pierce Hall, Rm 321 Cambridge MA 02138 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe O.","family":"Chantre","sequence":"additional","affiliation":[{"name":"Disease Biophysics Group Wyss Institute for Biologically Inspired Engineering Harvard University  29 Oxford St. Pierce Hall, Rm 321 Cambridge MA 02138 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