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Studies are reviewed that use covalent chemistries to fabricate cell\u2010instructive biointerfaces. These types of biointerfaces typically result in a static presentation of predefined cell\u2010instructive cues. Chemically defined, but dynamic cell\u2010instructive biointerfaces introduce spatiotemporal control over cell\u2010instructive cues and present another type of biointerface, which promises a more biomimetic way to guide cell behavior. Therefore, strategies that offer control over the lateral sorting of ligands, the availability and molecular structure of bioactive ligands, and strategies that offer the ability to induce physical, chemical and mechanical changes in situ are reviewed. Specific attention is paid to state\u2010of\u2010the\u2010art studies on dynamic, cell\u2010instructive 3D materials. Future work is expected to further deepen our understanding of molecular and cellular biological processes investigating cell\u2010type specific responses and the translational steps toward targeted in vivo applications.<\/jats:p>","DOI":"10.1002\/adhm.201701192","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T07:20:04Z","timestamp":1525245604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["About Chemical Strategies to Fabricate Cell\u2010Instructive Biointerfaces with Static and Dynamic Complexity"],"prefix":"10.1002","volume":"7","author":[{"given":"G\u00fclistan","family":"Ko\u00e7er","sequence":"first","affiliation":[{"name":"TechMed Centre and MESA<sup>+<\/sup> Institute for Nanotechnology University of Twente  7500 AE Enschede The Netherlands"},{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  Toronto M5S 3G9 Ontario 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