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These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. The flexible epidermal bandage sensor relies on printing stress\u2010enduring inks which display good resiliency against mechanical deformations, whereas the hollow microneedle device is filled with catechol\u2010coated carbon paste for assessing tissue TYR levels. The bandage sensor can thus be used directly on the skin whereas microneedle device can reach melanoma tissues under the skin. Both wearable sensors are interfaced to an ultralight flexible electronic board, which transmits data wirelessly to a mobile device. The analytical performance of the resulting bandage and microneedle sensing systems are evaluated using TYR\u2010containing agarose phantom gel and porcine skin. The new integrated conformal portable sensing platforms hold considerable promise for decentralized melanoma screening, and can be extended to the screening of other key biomarkers in skin moles.<\/jats:p>","DOI":"10.1002\/adhm.201701264","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T06:58:44Z","timestamp":1516258724000},"source":"Crossref","is-referenced-by-count":257,"title":["Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening"],"prefix":"10.1002","volume":"7","author":[{"given":"Bianca","family":"Ciui","sequence":"first","affiliation":[{"name":"Department of Nanoengineering University of California  San Diego La Jolla CA 92093 USA"},{"name":"Analytical Chemistry Department UMF  Cluj\u2010Napoca 400349 Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Nanoengineering University of California  San 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