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Numerous studies have demonstrated the potential of nanofibrous architecture to direct cell morphology, migration, and more complex biological processes such as differentiation and extracellular matrix (ECM) deposition through topographical guidance cues. These advantages have created great interest in electrospun fibers for biomedical applications, including tendon and ligament repair. Electrospun nanofibers, despite their nanoscale size, generally exhibit poor mechanical properties compared to larger conventionally manufactured polymer fiber materials. This invites the question of what role electrospun polymer nanofibers can play in tendon and ligament repair applications that have both biological and mechanical requirements. At first glance, the strength and stiffness of electrospun nanofiber grafts appear to be too low to fill the rigorous loading conditions of these tissues. However, there are a number of strategies to enhance and tune the mechanical properties of electrospun nanofiber grafts. As researchers design the next\u2010generation electrospun tendon and ligament grafts, it is critical to consider numerous physiologically relevant mechanical criteria and to evaluate graft mechanical performance in conditions and loading environments that reflect in vivo conditions and surgical fixation methods.<\/jats:p>","DOI":"10.1002\/adhm.201701277","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T01:43:12Z","timestamp":1522460592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Mechanical Considerations for Electrospun Nanofibers in Tendon and Ligament Repair"],"prefix":"10.1002","volume":"7","author":[{"given":"David A.","family":"Brennan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Rowan University  201 Mullica Hill Road, Rowan Hall Glassboro NJ 08028 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano A.","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University  201 Mullica Hill Road, Rowan Hall Glassboro NJ 08028 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kanski","sequence":"additional","affiliation":[{"name":"Cooper Bone and Joint Institute and Cooper Medical School, Rowan University  3 Cooper Plaza Camden NJ 08103 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Turkula","sequence":"additional","affiliation":[{"name":"Cooper Bone and Joint Institute and Cooper Medical School, Rowan University  3 Cooper Plaza Camden NJ 08103 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University  201 Mullica Hill Road, Rowan Hall Glassboro NJ 08028 USA"},{"name":"Department of Physics and Astronomy Rowan University  201 Mullica Hill Road, Rowan Hall Glassboro NJ 08028 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Kleiner","sequence":"additional","affiliation":[{"name":"Cooper Bone and Joint Institute and Cooper Medical School, Rowan University  3 Cooper Plaza Camden NJ 08103 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8550-3103","authenticated-orcid":false,"given":"Vince","family":"Beachley","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Rowan University  201 Mullica Hill Road, Rowan Hall Glassboro NJ 08028 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_11_1_1","volume-title":"Hierarchical Structures in Biology as a Guide for New Materials Technology","author":"National Material Advisory Board","year":"1994"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200600044"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.10.025"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31862"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2010.03.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328208099086"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb20795a"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/5\/4\/044109"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1318906"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.6.040803.140037"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.04.037"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.03.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jbm.a.32801","volume":"94","author":"Vaquette C.","year":"2010","journal-title":"J. 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