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Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex 3D structure with individualized size parameters, the significant compressive, tensile and shear loads encountered, and the poor blood supply. In this progress report, a review of the current clinical treatments for different types of meniscal injury is provided. The state\u2010of\u2010the\u2010art research in cellular therapies and novel cell sources for these therapies is discussed. The clinically available cell\u2010free biomaterial implants and the current progress on cell\u2010free biomaterial implants are reviewed. Cell\u2010based tissue engineering strategies for the repair and replacement of meniscus are presented, and the current challenges are identified. 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