{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:10:08Z","timestamp":1790266208824,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501859"],"award-info":[{"award-number":["81501859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030312004"],"award-info":[{"award-number":["2015A030312004"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), may provide new opportunities. In this work, the unique Cu<jats:sub>7.2<\/jats:sub>S<jats:sub>4<\/jats:sub> nanoparticles (NPs) are prepared for RA treatment enlightened by the fact that copper (Cu)\u2010based nanomaterials can simultaneously serve as PTT agents and photosensitizers (for PDT). Meanwhile, Cu can promote ostogenesis and chondrogenesis. The Cu<jats:sub>7.2<\/jats:sub>S<jats:sub>4<\/jats:sub> NPs combined with NIR (808 nm, 1 W cm<jats:sup>\u22122<\/jats:sup>) irradiation not only achieve better bone preservation, including higher bone mineral density (BMD) and bone volume\/total volume, but also inhibit inflamed synovial invasion, cartilage erosion, and expression of proinflammatory cytokines in vivo. Moreover, the Cu<jats:sub>7.2<\/jats:sub>S<jats:sub>4<\/jats:sub> NPs can effectively kill clinical pathogenic <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic> to prevent bacterial infection during intra\u2010articular injection. Therefore, the combined PTT and PDT using the multifunctional Cu<jats:sub>7.2<\/jats:sub>S<jats:sub>4<\/jats:sub> NPs could be a novel RA treatment modality with full potential.<\/jats:p>","DOI":"10.1002\/adhm.201800013","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T02:10:33Z","timestamp":1524795033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["A New Treatment Modality for Rheumatoid Arthritis: Combined Photothermal and Photodynamic Therapy Using Cu<sub>7.2<\/sub>S<sub>4<\/sub> Nanoparticles"],"prefix":"10.1002","volume":"7","author":[{"given":"Yao","family":"Lu","sequence":"first","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"},{"name":"Department of Orthopedics Zhujiang Hospital Southern Medical University  253 Gongye Road Guangzhou Guangdong 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"},{"name":"The China\u2010Germany Research Center for Photonic Materials and Device the State Key Laboratory of Luminescent Materials and Devices and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques the School of Materials Science and Engineering South China University of Technology  381 Wushan Road Guangzhou Guangdong 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"The China\u2010Germany Research Center for Photonic Materials and Device the State Key Laboratory of Luminescent Materials and Devices and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques the School of Materials Science and Engineering South China University of Technology  381 Wushan Road Guangzhou Guangdong 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhujiang Hospital Southern Medical University  253 Gongye Road Guangzhou Guangdong 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshui","family":"Yin","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhujiang Hospital Southern Medical University  253 Gongye Road Guangzhou Guangdong 510282 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xia","sequence":"additional","affiliation":[{"name":"Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA Department of Orthopedics Guangzhou School of Clinical Medicine Southern Medical University (Guangzhou General Hospital of Guangzhou Military Command of PLA)  111 Liuhua Road Guangzhou Guangdong 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12970"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn301215q"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2947"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn203190x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80049-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.12.024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4048205"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2016.1236262"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9732-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn302634m"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300694v"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102722z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704623"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-016-1208-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4011686"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB01086A"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-017-3992-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b15703"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB02002F"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.03.019"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.066"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33318"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b13750"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9151-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1978.tb06972.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00110"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbbm.2005.10.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400614"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2011.52.1.113"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/10480"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700073"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601453"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn403202w"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2016.2322"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"e_1_2_7_38_1","first-page":"387","volume":"35","author":"Smitten A. L.","year":"2008","journal-title":"J. Rheumatol."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.128637"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121075"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320422"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500712"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00258"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201800013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201800013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:08:58Z","timestamp":1759781338000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201800013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":43,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/adhm.201800013"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201800013","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]},"assertion":[{"value":"2018-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800013"}}