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Here, Wistar rats are used to study the anatomic and functional impact of electrospun nanofiber matrices eluting SN\u201038\u2014a potent chemotherapeutic agent\u2014on several body sites where pediatric tumors such as neuroblastoma, Ewing sarcoma, and rhabdomyosarcoma arise. Blank and SN\u201038\u2010loaded matrices embracing the femoral neurovascular bundle or in direct contact with abdominal viscera (liver, kidney, urinary bladder, intestine, and uterus) are placed. Foreign body tissue reaction to the implants is observed though no histologic damage in any tissue\/organ. Skin healing is normal. Tissue reaction is similar for SN\u201038\u2010loaded and blank matrices, with the exception of the hepatic capsule that is thicker for the former although within the limits consistent with mild foreign body reaction. Tissue and organ function is completely conserved after local treatments, as assessed by the rotarod test (forelimb function), hematologic tests (liver and renal function), and control of clinical signs. Overall, these findings support the clinical translation of SN\u201038\u2010loaded nanofiber matrices to improve local control strategies of surgically resected tumors.<\/jats:p>","DOI":"10.1002\/adhm.201800255","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T01:55:20Z","timestamp":1528768520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tissue Compatibility of SN\u201038\u2010Loaded Anticancer Nanofiber Matrices"],"prefix":"10.1002","volume":"7","author":[{"given":"Alejandro","family":"Manzanares","sequence":"first","affiliation":[{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona 08950 Spain"},{"name":"Department of Pediatric Hematology and Oncology Hospital Sant Joan de Deu  Barcelona 08950 Spain"},{"name":"Department of Pediatric Surgery Hospital Universitari Germans Trias i Pujol  Barcelona 08916 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