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However, its efficiency is restricted by the limited enhanced permeability and retention effect of nanomaterials and insufficient density\/specificity of receptors of tumor cells. Herein, an apoptosis\u2010homing nanoplatform based on zinc(II) dipicolylamine (ZnDPA) conjugated Fe\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles (MNPs\/ZnDPA), which demonstrates amplified magnetic resonance signal and photothermal therapy, is developed. In an apoptotic xenograft model constructed by doxorubicin, due to the high affinity between ZnDPA and the upregulated level of phosphatidylserine on the outer surface of apoptotic cancer cells, the accumulation value of MNPs\/ZnDPA is enhanced two\u2010fold and the tumor\/muscle ratio of <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values is decreased to 50% compared to that in the normal xenograft model. In the apoptotic xenograft model, the amplifying photothermal therapy is confirmed by the changes of the relative tumor volume and terminal deoxynucleotidyl transferase\u2010mediated dUTP\u2010biotin nick end\u2010labeling staining. This nanoplatform provides a promising strategy to improve the targeting efficiency of nanoparticles and the enhancement of tumor\u2010targeting theranostics.<\/jats:p>","DOI":"10.1002\/adhm.201800296","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T04:40:22Z","timestamp":1525927222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Amplifying Apoptosis Homing Nanoplatform for Tumor Theranostics"],"prefix":"10.1002","volume":"7","author":[{"given":"Heng","family":"Zhao","sequence":"first","affiliation":[{"name":"The Key Laboratory of Resource Chemistry of Ministry of Education Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors Shanghai Normal University  Shanghai 200234 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