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For the first reported time, nanoscaled PG is prepared using an environmentally friendly ball\u2010milling technique. The unique 2D nanostructure obtained using this PG synthesis approach offers considerable advantages in terms of drug loading and delivery, as well as the conjugation of Tf to PG providing a more targeted delivery vehicle. A highly efficient targeted pathway toward OCM\u20101 cells triggered by an affinity between Tf and Tf receptors expressed on the surface of OCM\u20101 cells is reported first here. PG\u2010Tf is observed to easily anchor anticancer drugs such as doxorubicin via \u03c0\u2013\u03c0 stacking. This work performs a Transwell two cells coculture experiment, a 3D in vitro tumor model, and an in vivo mouse model with OCM\u20101 tumors to demonstrate the composite's therapeutic superiority over conventional systems for the targeted delivery and controlled release of antitumor drugs.<\/jats:p>","DOI":"10.1002\/adhm.201800377","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T09:16:37Z","timestamp":1530263797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Transferrin Triggered Pathway for Highly Targeted Delivery of Graphene\u2010Based Nanodrugs to Treat Choroidal Melanoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Bingxin","family":"Zhao","sequence":"first","affiliation":[{"name":"Laboratory of Nanoscale Biosensing and Bioimaging School of Ophthalmology and Optometry\/School of Biomedical Engineering State Key Laboratory of Ophthalmology Optometry and 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