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Although GNPs exhibit excellent therapeutic efficacy in in vitro and in vivo in numerous studies, there still exists significant biosafety concerns, mainly for their nonbiodegradability and tendency to be trapped in the liver and spleen. To tackle this problem, hexapeptides are utilized to modify the GNP surface to not only impart them with potent anti\u2010inflammatory activity, but also facilitate their rapid clearance in vivo. Previously, a unique class of peptide\u2010GNP hybrids that potently inhibit multiple TLR signaling pathways in macrophages was identified; in this work, it is further demonstrated that these hybrids, after intratracheal instillation, are capable of effectively reducing lung inflammation and injury by decreasing neutrophil infiltration and increasing the number of regulatory T cells in the lung in a lipopolysaccharide\u2010induced acute lung injury (ALI) mouse model. More importantly, these hybrids can be effectively excreted 26 h post\u2010administration with only 8.49 \u00b1 0.70% of them remaining in the body, primarily in the lung and intestine and less than 0.03% accumulated in the liver and spleen. This work provides strong evidences that properly designed peptide\u2010GNP hybrids can serve as the next generation of effective and safe anti\u2010inflammatory nanotherapeutics to treat ALI.<\/jats:p>","DOI":"10.1002\/adhm.201800510","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T02:20:10Z","timestamp":1534126810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Peptide\u2013Gold Nanoparticle Hybrids as Promising Anti\u2010Inflammatory Nanotherapeutics for Acute Lung Injury: In Vivo Efficacy, Biodistribution, and Clearance"],"prefix":"10.1002","volume":"7","author":[{"given":"Ye","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"},{"name":"Department of Pulmonary and Critical Care Medicine Changhai Hospital Second Military Medical University  Shanghai 200433 China"},{"name":"Department of Pulmonary and Critical Care Medicine Shanghai East Hospital Tongji University  Shanghai 200120 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Medicine, 85 Hospital of People's Liberation Army  Shanghai 200052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suqin","family":"Ben","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Shanghai General Hospital Shanghai Jiaotong University School of Medicine  Shanghai 201620 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart E.","family":"Turvey","sequence":"additional","affiliation":[{"name":"BC Children's Hospital and Child &amp; 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