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The aim of this study is to evaluate the pharmacodynamics of Abextide in nonhuman primates. Two batches of elderly cynomolgus monkeys with naturally occurring diabetes are used for this study. During the whole experiment period, no abnormalities such as swelling at the injection site, lethargy, or hypoglycemia are observed in all animals. The monkeys in the Abextide group lose appetite after drug administration and then recover over time. In the single dose treatment, at day 1 and day 3 after treatment, decreased plasma glucose level is observed in the Abextide\u2010treated group but not in placebo or Albiglutide\u2010treated group. For monkeys that receive two doses of drug, the blood glucose level in all subjects in Abextide group decreases rapidly upon drug administration and return to a plateau by day 3. A similar pattern of response is seen after the second dose administration. The delayed drug release and hypoglycemic effect of Abextide make it potentially useful as an antidiabetic drug for weekly subcutaneous administration.<\/jats:p>","DOI":"10.1002\/adhm.201800686","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T19:44:17Z","timestamp":1539114257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antidiabetic Effect of Abextide, a Long\u2010Acting Exendin\u20104 Analogue in Cynomolgus Monkeys"],"prefix":"10.1002","volume":"8","author":[{"given":"Gang","family":"Niu","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH)  9000 Rockville Pike Bethesda MD 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key 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