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The PbS seed size and CdS shell thicknesses are carefully controlled to produce bright and narrow fluorescence that are suitable for multiplexing. A polymer encapsulation yields polymer\u2010encapsulated NIR\u2010II QDs (PQDs), which provides the QDs with long\u2010term fluorescence stability over a week in biological media. Exploiting the simple bioconjugation capability of PQDs, folic acids are conjugated to PQDs that can efficiently label folate receptor overexpressing cell lines. The PQDs afford multiplexed and nearly real\u2010time longitudinal whole\u2010body in vivo imaging. Two NIR\u2010II QD probes are prepared: folic acid\u2010conjugated PQDs (FA\u2010PQDs) emitting at 1280 nm and unconjugated PQDs emitting at 1080 nm. The two PQDs are engineered to have compact and similar hydrodynamic sizes. A mixture of the folic acid\u2010conjugated PQD and unconjugated PQDs is injected intravenously into a tumor\u2010xenografted mouse, and the signals from them are monitored. This NIR\u2010II whole\u2010body imaging with the two PQDs provides precise evaluation of the active ligand\u2010assisted tumor\u2010targeting capability of the FA\u2010PQD probe because the hydrodynamic size control of the two PQDs effectively eliminates effects from the size\u2010dependent accumulations by permeations and retentions in tumors.<\/jats:p>","DOI":"10.1002\/adhm.201800695","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T06:48:35Z","timestamp":1542610115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Multiplexed In Vivo Imaging Using Size\u2010Controlled Quantum Dots in the Second Near\u2010Infrared Window"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-0346","authenticated-orcid":false,"given":"Sanghwa","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Chemistry Pohang University of Science 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