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The embedded therapeutic drugs, however, are largely limited to hydrophobic small molecules. By transferring proteins into organic solvent via hydrophobic ion pairing, the scope of FNP applications is expanded. This platform technology is capable of producing protein nanoparticles with tunable sizes (from \u224830 nm to sub\u2010micrometers), high\u2010production scale (grams per hour), high drug loading efficiency (&gt;90%), and excellent reproducibility, opening a new paradigm for formulation of biological pharmaceuticals. As a proof\u2010of\u2010concept, insulin nanoparticles are made to address a major medical challenge; oral administration. 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