{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:06:53Z","timestamp":1793066813307,"version":"4.5.0"},"reference-count":170,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL123920"],"award-info":[{"award-number":["HL123920"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL137093"],"award-info":[{"award-number":["HL137093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Mounting evidence supports the theory that paracrine products are the main contributors to the regenerative effects attributed to these cell therapies. The next generation of cell\u2010based MI therapies will identify and isolate cell products and derivatives, integrate them with biocompatible materials and technologies, and use them for the regeneration of damaged myocardial tissue. This review discusses the progress made thus far in pursuit of this new generation of cell therapies. Their fundamental regenerative mechanisms, their potential to combine with other therapeutic products, and their role in shaping new clinical approaches for heart tissue engineering, are addressed.<\/jats:p>","DOI":"10.1002\/adhm.201801011","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T03:05:19Z","timestamp":1544670319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["A New Era of Cardiac Cell Therapy: Opportunities and Challenges"],"prefix":"10.1002","volume":"8","author":[{"given":"Ke","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-7224","authenticated-orcid":false,"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University  Raleigh NC 27607 USA"},{"name":"Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University  Raleigh NC 27607 USA"},{"name":"Pharmacoengineeirng and Molecular Pharmaceutics Division University of North Carolina at Chapel Hill  Chapel Hill NC 27599 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"Benjamin E. J.","year":"2017","journal-title":"Circulation"},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/CIRCULATIONAHA.108.813493","volume":"118","author":"Jhund P. S.","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","volume":"101","author":"St. John Sutton M. G.","year":"2000","journal-title":"Circulation"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.scr.2014.06.003","volume":"13","author":"Porrello E. R.","year":"2014","journal-title":"Stem Cell Res."},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/emmm.201100175","volume":"3","author":"Steinhauser M. L.","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.devcel.2016.01.018","volume":"36","author":"Uygur A.","year":"2016","journal-title":"Dev. Cell"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s11936-013-0288-8","volume":"16","author":"Gamba L.","year":"2014","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/dvdy.24154","volume":"243","author":"Ito K.","year":"2014","journal-title":"Dev. Dyn."},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1021\/acs.jproteome.7b00915","volume":"17","author":"Ma D.","year":"2018","journal-title":"J. Proteome Res."},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"Bergmann O.","year":"2009","journal-title":"Science"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1056\/NEJM200106073442303","volume":"344","author":"Beltrami A. P.","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","volume":"173","author":"Mohamed T. M. A.","year":"2018","journal-title":"Cell"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s12013-014-0369-7","volume":"71","author":"Song G.","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-017-01946-x","volume":"8","author":"Shadrin I. Y.","year":"2017","journal-title":"Nat. Commun."},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-319-25427-2_2","volume-title":"Stem cells and cardiac regeneration","author":"Moccia F.","year":"2016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(12)60195-0","volume":"379","author":"Makkar R. R.","year":"2012","journal-title":"Lancet"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","volume":"63","author":"Konstantinos Malliaras P.","year":"2014","journal-title":"J. Am. College Cardiol."},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"e13480","DOI":"10.14814\/phy2.13480","volume":"5","author":"Elmadbouh I.","year":"2017","journal-title":"Physiol. Rep."},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1073\/pnas.0504388102","volume":"102","author":"Amado L. C.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_9_20_1","first-page":"822","volume":"12","author":"Miana V. V.","year":"2018","journal-title":"eCancer Med. Sci."},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.yjmcc.2010.08.005","volume":"50","author":"Mirotsou M.","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","volume":"103","author":"Gnecchi M.","year":"2008","journal-title":"Circ. Res."},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1755-1536-1-4","volume":"1","author":"Burchfield J. S.","year":"2008","journal-title":"Fibrog. Tissue Repair"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm0405-367","volume":"11","author":"Gnecchi M.","year":"2005","journal-title":"Nat. Med."},{"key":"e_1_2_9_25_1","first-page":"H1726","volume":"295","author":"Crisostomo P. R.","year":"2008","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/jcmm.12585","volume":"19","author":"Hensley M. T.","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jacc.2014.02.209","volume":"2","author":"Cheng K.","year":"2014","journal-title":"JACC: Heart Fail."},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5966\/sctm.2015-0194","volume":"5","author":"Shen D.","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/CIRCRESAHA.115.305373","volume":"118","author":"Hodgkinson C. P.","year":"2016","journal-title":"Circ. Res."},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"a006502","DOI":"10.1101\/cshperspect.a006502","volume":"2","author":"Koch S.","year":"2012","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"e_1_2_9_31_1","first-page":"1","volume":"17","author":"Talwar T.","year":"2014","journal-title":"Ann. Indian Acad. Neurol."},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3390\/biomedicines2040247","volume":"2","author":"Gallo S.","year":"2014","journal-title":"Biomedicines"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00018-011-0633-6","volume":"68","author":"Sala V.","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/sctm.17-0172","volume":"7","author":"Mayorga M. E.","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2003-12-4423","volume":"104","author":"Falco E.","year":"2004","journal-title":"Blood"},{"key":"e_1_2_9_36_1","first-page":"H1565","volume":"298","author":"Yoshida T.","year":"2010","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbadis.2017.10.001","volume":"1864","author":"Gan W.","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.bbadis.2013.09.004","volume":"1832","author":"Mishra P. K.","year":"2013","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ceb.2018.05.008","volume":"55","author":"Sandoval\u2010Guzm\u00e1n T.","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"e_1_2_9_40_1","first-page":"1437","volume":"17","author":"Li L. L.","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1749-6632.2010.05479.x","volume":"1194","author":"Philp D.","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature10188","volume":"474","author":"Smart N.","year":"2011","journal-title":"Nature"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9630175","volume":"2018","author":"Shah R.","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/CIRCRESAHA.114.300556","volume":"114","author":"Lalit P. A.","year":"2014","journal-title":"Circ. Res."},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1161\/CIRCRESAHA.117.310803","volume":"121","author":"Tachibana A.","year":"2017","journal-title":"Circ. Res."},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41551-018-0229-7","volume":"2","author":"Liu B.","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","volume":"53","author":"Frangogiannis N. G.","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1021\/acsnano.6b04989","volume":"10","author":"Ye Y.","year":"2016","journal-title":"ACS Nano"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10753-007-9025-3","volume":"30","author":"Guo J.","year":"2007","journal-title":"Inflammation"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cophys.2017.09.001","volume":"1","author":"Frangogiannis N. G.","year":"2018","journal-title":"Curr. Opin. Physiol."},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","volume":"48","author":"Dobaczewski M.","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.omtm.2017.06.005","volume":"6","author":"Nakajima M.","year":"2017","journal-title":"Mol. Ther.\u2013Methods Clin. Dev."},{"key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.118.035047","volume":"138","author":"Shirakawa K.","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/s41467-018-04908-z","volume":"9","author":"Zacchigna S.","year":"2018","journal-title":"Nat. Commun."},{"key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/sctm.17-0196","volume":"7","author":"Tang J.","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5966\/sctm.2014-0110","volume":"4","author":"Heslop J. A.","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/stem.1184","volume":"30","author":"Cheng K.","year":"2012","journal-title":"Stem Cells"},{"key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/stem.2451","volume":"35","author":"Allen T. A.","year":"2017","journal-title":"Stem Cells"},{"key":"e_1_2_9_59_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ebiom.2017.01.029","volume":"16","author":"Duelen R.","year":"2017","journal-title":"EBioMedicine"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.108.812693","volume":"119","author":"Philippe M.","year":"2009","journal-title":"Circulation"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/heartjnl-2017-311684","volume":"104","author":"Fisher S. A.","year":"2018","journal-title":"Heart"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/CIRCRESAHA.117.311589","volume":"122","author":"Mayourian J.","year":"2018","journal-title":"Circ. Res."},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-016-0009-6","volume":"8","author":"Tang J.","year":"2017","journal-title":"Nat. Commun."},{"key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCRESAHA.116.310374","volume":"120","author":"Luo L.","year":"2017","journal-title":"Circ. Res."},{"key":"e_1_2_9_65_1","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1021\/acsnano.8b01977","volume":"12","author":"Mihalko E.","year":"2018","journal-title":"ACS Nano"},{"key":"e_1_2_9_66_1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.7150\/thno.20524","volume":"8","author":"Vandergriff A.","year":"2018","journal-title":"Theranostics"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41551-017-0182-x","volume":"2","author":"Tang J.","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"e_1_2_9_68_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actbio.2016.08.031","volume":"44","author":"Sarig U.","year":"2016","journal-title":"Acta Biomater."},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/nl500618u","volume":"14","author":"Fang R. H.","year":"2014","journal-title":"Nano Lett."},{"key":"e_1_2_9_70_1","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1021\/acsnano.8b00553","volume":"12","author":"Liang H.","year":"2018","journal-title":"ACS Nano"},{"key":"e_1_2_9_71_1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1021\/acsnano.7b08219","volume":"12","author":"Pei Q.","year":"2018","journal-title":"ACS Nano"},{"key":"e_1_2_9_72_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1039\/C3NR05444F","volume":"6","author":"Hu C.\u2010M. J.","year":"2014","journal-title":"Nanoscale"},{"key":"e_1_2_9_73_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2014.10.007","volume":"82","author":"Tran C.","year":"2015","journal-title":"Adv. Drug Delivery Rev."},{"key":"e_1_2_9_74_1","doi-asserted-by":"crossref","first-page":"37606","DOI":"10.1038\/srep37606","volume":"6","author":"Liu P.","year":"2016","journal-title":"Sci. Rep."},{"key":"e_1_2_9_75_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13287-015-0124-z","volume":"6","author":"Teixeira F. G.","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"e_1_2_9_76_1","doi-asserted-by":"crossref","first-page":"1700341","DOI":"10.1002\/pmic.201700341","volume":"18","author":"Ahn C.\u2010S.","year":"2018","journal-title":"Proteomics"},{"key":"e_1_2_9_77_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.7150\/thno.18133","volume":"7","author":"Li P.","year":"2017","journal-title":"Theranostics"},{"key":"e_1_2_9_78_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","volume":"109","author":"Sahoo S.","year":"2011","journal-title":"Circ. Res."},{"key":"e_1_2_9_79_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4939-7601-0_10","volume-title":"MicroRNA protocols","author":"Ong S.\u2010G.","year":"2018"},{"key":"e_1_2_9_80_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2014.05.004","volume":"29","author":"Kowal J.","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"e_1_2_9_81_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.scr.2013.01.002","volume":"10","author":"Arslan F.","year":"2013","journal-title":"Stem Cell Res."},{"key":"e_1_2_9_82_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"He C.","year":"2018","journal-title":"Theranostics"},{"key":"e_1_2_9_83_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCRESAHA.114.300639","volume":"114","author":"Sahoo S.","year":"2014","journal-title":"Circ. Res."},{"key":"e_1_2_9_84_1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1590\/1414-431X20132964","volume":"46","author":"Borges F. T.","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"e_1_2_9_85_1","doi-asserted-by":"crossref","first-page":"60149","DOI":"10.18632\/oncotarget.18557","volume":"8","author":"Yan S.","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_9_86_1","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/CIRCULATIONAHA.112.114173","volume":"126","author":"Lee C.","year":"2012","journal-title":"Circulation"},{"key":"e_1_2_9_87_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/CIRCRESAHA.115.307654","volume":"118","author":"Kishore R.","year":"2016","journal-title":"Circ. Res."},{"key":"e_1_2_9_88_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stemcr.2014.04.006","volume":"2","author":"Ibrahim A. G.\u2010E.","year":"2014","journal-title":"Stem Cell Rep."},{"key":"e_1_2_9_89_1","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1021\/pr201025m","volume":"11","author":"Li X.","year":"2012","journal-title":"J. Proteome Res."},{"key":"e_1_2_9_90_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.21037\/sci.2017.11.06","volume":"4","author":"Barile L.","year":"2017","journal-title":"Stem Cell Invest."},{"key":"e_1_2_9_91_1","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.bbadis.2015.08.010","volume":"1852","author":"Essandoh K.","year":"2015","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"e_1_2_9_92_1","first-page":"201","volume":"38","author":"Gallet R.","year":"2017","journal-title":"Eur. Heart J."},{"key":"e_1_2_9_93_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/CIRCRESAHA.117.305990","volume":"117","author":"Khan M.","year":"2015","journal-title":"Circ. Res."},{"key":"e_1_2_9_94_1","doi-asserted-by":"crossref","first-page":"e001260","DOI":"10.1161\/JAHA.114.001260","volume":"3","author":"Cheng K.","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"e_1_2_9_95_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.atherosclerosis.2011.03.034","volume":"217","author":"Vasa\u2010Nicotera M.","year":"2011","journal-title":"Atherosclerosis"},{"key":"e_1_2_9_96_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.118.312420","volume":"122","author":"Mayourian J.","year":"2018","journal-title":"Circ. Res."},{"key":"e_1_2_9_97_1","doi-asserted-by":"crossref","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","volume":"7","author":"Tian Y.","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"e_1_2_9_98_1","doi-asserted-by":"crossref","first-page":"20844","DOI":"10.1073\/pnas.0710558105","volume":"104","author":"Liu N.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_9_99_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","volume":"129","author":"Zhao Y.","year":"2007","journal-title":"Cell"},{"key":"e_1_2_9_100_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","volume":"15","author":"Fish J. E.","year":"2008","journal-title":"Dev. Cell"},{"key":"e_1_2_9_101_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","volume":"103","author":"Barile L.","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"e_1_2_9_102_1","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1101\/gad.1738708","volume":"22","author":"Liu N.","year":"2008","journal-title":"Genes Dev."},{"key":"e_1_2_9_103_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCRESAHA.111.248880","volume":"109","author":"Wang X.","year":"2011","journal-title":"Circ Res."},{"key":"e_1_2_9_104_1","doi-asserted-by":"crossref","unstructured":"E. R.Porrello B. A.Johnson A. B.Aurora E.Simpson Y.Nam S. J.Matkovich G. W. D.Ii E.VanRooij E. N.Olson 2011 670.","DOI":"10.1161\/CIRCRESAHA.111.248880"},{"key":"e_1_2_9_105_1","first-page":"9102909","volume":"2017","author":"Gu H.","year":"2017","journal-title":"Biomed Res int."},{"key":"e_1_2_9_106_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijcard.2014.12.043","volume":"182","author":"Yu B.","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"e_1_2_9_107_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijcard.2015.06.163","volume":"201","author":"Liang D.","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"e_1_2_9_108_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5966\/sctm.2015-0386","volume":"6","author":"Wang K.","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_109_1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.bbadis.2017.02.023","volume":"1863","author":"Wang N.","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"e_1_2_9_110_1","doi-asserted-by":"crossref","first-page":"e88685","DOI":"10.1371\/journal.pone.0088685","volume":"9","author":"Feng Y.","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_9_111_1","doi-asserted-by":"crossref","first-page":"354517","DOI":"10.1155\/2015\/354517","volume":"2015","author":"Chistiakov D. A.","year":"2015","journal-title":"Biomed Res Int."},{"key":"e_1_2_9_112_1","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","volume":"119","author":"Callis T. E.","year":"2009","journal-title":"J. Clin. Invest."},{"key":"e_1_2_9_113_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2013.01.015","volume":"431","author":"Chen L.","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_2_9_114_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/CIRCULATIONAHA.110.982918","volume":"123","author":"Hosoda T.","year":"2011","journal-title":"Circulation"},{"key":"e_1_2_9_115_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/971907","volume":"2012","author":"Lai R. C.","year":"2012","journal-title":"Int. J. Proteomics"},{"key":"e_1_2_9_116_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/gkp857","volume":"38","author":"Chen T. S.","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"e_1_2_9_117_1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1161\/CIRCRESAHA.116.309942","volume":"119","author":"Davis M. E.","year":"2016","journal-title":"Circ. Res."},{"key":"e_1_2_9_118_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/aps.2018.18","volume":"39","author":"Ruan X.","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"e_1_2_9_119_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm1394","volume":"12","author":"Zimmermann W.\u2010H.","year":"2006","journal-title":"Nat. Med."},{"key":"e_1_2_9_120_1","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1161\/CIRCULATIONAHA.111.084343","volume":"126","author":"Kawamura M.","year":"2012","journal-title":"Circulation"},{"key":"e_1_2_9_121_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11936-015-0399-5","volume":"17","author":"Zhang J.","year":"2015","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"e_1_2_9_122_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCRESAHA.118.311213","volume":"123","author":"Zhang J.","year":"2018","journal-title":"Circ. Res."},{"key":"e_1_2_9_123_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbrc.2009.07.024","volume":"387","author":"Suzuki R.","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_2_9_124_1","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.0908381106","volume":"106","author":"Stevens K. R.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_9_125_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1089\/ten.tea.2010.0557","volume":"17","author":"Kreutziger K. L.","year":"2011","journal-title":"Tissue Eng., Part A"},{"key":"e_1_2_9_126_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/term.2568","volume":"12","author":"Schaefer J. A.","year":"2018","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"e_1_2_9_127_1","doi-asserted-by":"crossref","first-page":"e384","DOI":"10.1002\/term.2392","volume":"12","author":"O'Neill H. S.","year":"2016","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"e_1_2_9_128_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3390\/ijms19041032","volume":"19","author":"Becker M.","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_9_129_1","doi-asserted-by":"crossref","first-page":"1800672","DOI":"10.1002\/adhm.201800672","volume":"0","author":"Bejleri D.","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_9_130_1","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1021\/acsnano.7b01008","volume":"11","author":"Tang J.","year":"2017","journal-title":"ACS Nano"},{"key":"e_1_2_9_131_1","doi-asserted-by":"crossref","first-page":"33088","DOI":"10.1021\/acsami.8b13571","volume":"10","author":"Su T.","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_9_132_1","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.117.030785","volume":"137","author":"Gao L.","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_9_133_1","first-page":"342ps13","volume":"8","author":"Ogle B. M.","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"e_1_2_9_134_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1089\/ten.tec.2016.0492","volume":"23","author":"Tang J.","year":"2017","journal-title":"Tissue Eng., Part C"},{"key":"e_1_2_9_135_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5966\/sctm.2015-0194","volume":"5","author":"Shen D.","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"e_1_2_9_136_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41551-017-0157-y","volume":"1","author":"Wang L. L.","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"e_1_2_9_137_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actbio.2016.08.031","volume":"44","author":"Sarig U.","year":"2016","journal-title":"Acta Biomater."},{"key":"e_1_2_9_138_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","volume":"547","author":"Bassat E.","year":"2017","journal-title":"Nature"},{"key":"e_1_2_9_139_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2017.12.019","volume":"68","author":"Spang M. T.","year":"2018","journal-title":"Acta Biomater."},{"key":"e_1_2_9_140_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nmat4956","volume":"16","author":"Montgomery M.","year":"2017","journal-title":"Nat. Mater."},{"key":"e_1_2_9_141_1","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.athoracsur.2012.11.020","volume":"95","author":"Cannata A.","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"e_1_2_9_142_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13019-016-0559-z","volume":"11","author":"Sugiura T.","year":"2016","journal-title":"J. Cardiothorac. Surg."},{"key":"e_1_2_9_143_1","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1021\/acs.nanolett.7b04924","volume":"18","author":"Malki M.","year":"2018","journal-title":"Nano Lett."},{"key":"e_1_2_9_144_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11748-007-0144-4","volume":"55","author":"Fujimatsu T.","year":"2007","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"e_1_2_9_145_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","volume":"510","author":"Chong J. J.","year":"2014","journal-title":"Nature"},{"key":"e_1_2_9_146_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1208\/s12248-010-9175-3","volume":"12","author":"Morais J. M.","year":"2010","journal-title":"AAPS J."},{"key":"e_1_2_9_147_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.yjmcc.2011.02.003","volume":"50","author":"Kanki S.","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"e_1_2_9_148_1","doi-asserted-by":"crossref","first-page":"eaan6205","DOI":"10.1126\/scitranslmed.aan6205","volume":"10","author":"Miragoli M.","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"e_1_2_9_149_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3390\/jfb6030526","volume":"6","author":"Cores J.","year":"2015","journal-title":"J. Funct. Biomater."},{"key":"e_1_2_9_150_1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.2217\/nnm.12.109","volume":"7","author":"Sensenig R.","year":"2012","journal-title":"Nanomedicine"},{"key":"e_1_2_9_151_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/anie.200602866","volume":"46","author":"Lu A.\u2010H.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_9_152_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/01.TP.0000089237.39220.83","volume":"76","author":"Arbab A. S.","year":"2003","journal-title":"Transplantation"},{"key":"e_1_2_9_153_1","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1021\/am400249n","volume":"5","author":"Chen J.","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_9_154_1","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1016\/j.biomaterials.2014.06.031","volume":"35","author":"Vandergriff A. C.","year":"2014","journal-title":"Biomaterials"},{"key":"e_1_2_9_155_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1634\/stemcells.2005-0602","volume":"25","author":"Lee R. J.","year":"2009","journal-title":"Stem Cells"},{"key":"e_1_2_9_156_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2174\/157340312803217247","volume":"8","author":"Srikanth S.","year":"2012","journal-title":"Curr. Cardiol. Rev."},{"key":"e_1_2_9_157_1","first-page":"641","volume":"2","author":"Nesheim M.","year":"2001","journal-title":"Ital. Hear. J."},{"key":"e_1_2_9_158_1","first-page":"375","volume-title":"Microgels in Drug Delivery","author":"Malmsten M.","year":"2011"},{"key":"e_1_2_9_159_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tibtech.2013.08.007","volume":"31","author":"Byrne H.","year":"2013","journal-title":"Trends Biotechnol."},{"key":"e_1_2_9_160_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature10673","volume":"480","author":"Mellman I.","year":"2011","journal-title":"Nature"},{"key":"e_1_2_9_161_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1517\/14712598.2015.1049944","volume":"15","author":"Tang J.","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"key":"e_1_2_9_162_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bcmd.2003.09.019","volume":"32","author":"Lum L. G.","year":"2004","journal-title":"Blood Cells, Mol., Dis."},{"key":"e_1_2_9_163_1","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1038\/ncomms5880","volume":"5","author":"Cheng K.","year":"2014","journal-title":"Nat. Commun."},{"key":"e_1_2_9_164_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrcardio.2011.91","volume":"8","author":"Lippi G.","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"e_1_2_9_165_1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2217\/nnm.13.113","volume":"8","author":"Modery\u2010Pawlowski C. L.","year":"2013","journal-title":"Nanomedicine"},{"key":"e_1_2_9_166_1","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1182\/blood-2006-12-027698","volume":"109","author":"Jackson S. P.","year":"2007","journal-title":"Blood"},{"key":"e_1_2_9_167_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature15373","volume":"526","author":"Hu C.\u2010M.","year":"2015","journal-title":"Nature"},{"key":"e_1_2_9_168_1","first-page":"1803567","volume":"0","author":"Su T.","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_9_169_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/19420862.2015.1007813","volume":"7","author":"Overdijk M. B.","year":"2015","journal-title":"mAbs"},{"key":"e_1_2_9_170_1","first-page":"41","volume":"12","author":"Muzykantov V.","year":"2011","journal-title":"Int. J. Transp. Phenom."}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201801011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201801011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201801011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201801011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:08:51Z","timestamp":1759745331000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201801011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":170,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/adhm.201801011"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201801011","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]},"assertion":[{"value":"2018-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1801011"}}