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However, current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber\u2010optic probes to deliver visible light into organs and animal tissues. This often results in a series of side effects, such as tissue damage and unwanted inflammation. Fortunately, the emerging wireless optogenetic tools that can respond to deep\u2010tissue\u2010penetrating near\u2010infrared (NIR) light have attracted increasing attention due to their much\u2010reduced damage to living organisms. There are mainly two types of NIR\u2010activatable optogenetic tools: one uses lanthanide\u2010doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin\u2010expressing neurons; the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins. These NIR\u2010activatable optogenetic tools enable low\u2010invasive \u201cremote control\u201d activation and inhibition of cellular signaling pathways. This approach has great potential to help create more innovative therapies for diseases like cancer, diabetes, and neuronal disorders in the near future. Therefore, this review article summarizes the recent advances on design strategies and synthetic methods of NIR\u2010activatable nanomaterials for wireless optogenetic applications.<\/jats:p>","DOI":"10.1002\/adhm.201801132","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T12:54:15Z","timestamp":1547211255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Near\u2010Infrared\u2010Light Activatable Nanoparticles for Deep\u2010Tissue\u2010Penetrating Wireless Optogenetics"],"prefix":"10.1002","volume":"8","author":[{"given":"Nuo","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School  Worcester MA 01605 USA"},{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University  Shanghai 201620 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