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The aim of this work is to develop a silk fibroin (SF)\u2010based nanofibrous membrane that is loaded with combined\u2010therapy drugs by using electrospinning technologies, which is further coated on a polydioxanone (PDO) stent and used for the treatment of colorectal cancer (CRC). In order to improve treatment effectiveness, a combination of therapeutic drugs, i.e., curcumin (CUR) and 5\u2010fluorouracil (5\u2010FU), is dissolved into SF solution and then eletrospun onto the surface of the PDO stent. The morphology, secondary structure, and in vitro drug release profiles of the membranes are characterized. The antitumor efficacy is assessed in vitro and in vivo using a human CRC cell line and normal cells, and tumor\u2010bearing nude mice. In vitro and in vivo studies on the nanofibrous memembrane\u2010coating demonstrate improved antitumor effects for the CUR\/5\u2010FU dual drug system which can be attributed to cell cycle arrest in the S phase in association with induced apoptosis in tumor cells by blocking signal transducer and activator of transcription3 (Stat3) and nuclear factor kappa beta (NF\u2010kB) signaling pathways, suggesting potential in the treatment of CRC in the future.<\/jats:p>","DOI":"10.1002\/adhm.201801213","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T11:26:07Z","timestamp":1542972367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["A Biodegradable Stent with Surface Functionalization of Combined\u2010Therapy Drugs for Colorectal Cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Xusheng","family":"Xie","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University  Suzhou 215123 P. 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