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Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.<\/jats:p>","DOI":"10.1002\/adhm.201801236","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T04:17:08Z","timestamp":1545020228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Tissue Engineering for the Temporomandibular Joint"],"prefix":"10.1002","volume":"8","author":[{"given":"Timothy M.","family":"Acri","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsup","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics College of Dentistry and Dental Clinics University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongrim","family":"Seol","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation Carver College of Medicine University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah Z.","family":"Laird","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ino","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation Carver College of Medicine University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Geary","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaidev L.","family":"Chakka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation Carver College of Medicine University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-6633","authenticated-orcid":false,"given":"Aliasger K.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa  Iowa City, Iowa 52242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-5950.94463"},{"key":"e_1_2_9_2_1","volume-title":"Dorland's Illustrated Medical Dictionary","author":"Dorland W. 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