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The ability to selectively fast\u2010heat tumor tissues over surrounding compartments is of fundamental importance and makes effective treatment of tumor margins and complex tumor geometries. Currently existing chemo\u2010photothermal methods mainly show slow light\u2010to\u2010heat conversion with increased temperature up to around 45\u201357 \u00b0C for 5\u201320 min or a longer time in vitro under regular near\u2010infrared laser irradiation, and during tumor therapy, worse performance in temperature changes are obtained due to the much longer penetration distance in vivo. Herein, nanoarchitectonics with excellent chemo\u2010photothermal performance are first proposed for tumors via in situ decoration of nanogold flowers on graphene oxide surface with further modification of the aptamer molecule. Even with simple synthesis processes, these nanoarchitectonics demonstrate impressive increased temperatures up to 85 \u00b0C in just 2 min under 808 nm laser irradiation with regular power density. Due to the fast light\u2010to\u2010heat conversion ability and specific binding effect between the aptamer and tumor cells, the designed nanocarrier shows a rapid and target therapy system with a targeted chemo\u2010photothermal tumor treatment.<\/jats:p>","DOI":"10.1002\/adhm.201801300","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T03:29:43Z","timestamp":1550201383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Nanogold Flower\u2010Inspired Nanoarchitectonics Enables Enhanced Light\u2010to\u2010Heat Conversion Ability for Rapid and Targeted Chemo\u2010Photothermal Therapy of a Tumor"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-5680","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers College of Chemistry and Chemical Engineering Linyi University  Linyi 276005 P. 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