{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:27:56Z","timestamp":1762867676341,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB002520"],"award-info":[{"award-number":["P41EB002520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Otitis media with effusion (OEM) is a common pediatric pathology treated with topical fluoroquinolones (ear drops) and tympanoplasty tube, also referred to as ear tube, implantation for middle ear drainage. Commercially available ear tubes are fabricated using poly (lactic\u2010co\u2010glycolic acid) synthetic materials that are associated with long\u2010complications due to premature extrusion. Resorbable materials have emerged as desirable alternatives to reduce extrusion\u2010related complications, but often limited by fast resorption rates. Therefore, resorbable tubes with long\u2010term functional integrity are required for future clinical translation. In this communication, a proof\u2010of\u2010concept study is reported on a bioresorbable and drug\u2010eluting silk ear tube device. Preliminary in vitro assessments reveal time\u2010dependent drug elution and antimicrobial properties, while maintaining long\u2010term functional integrity in vivo. This report provides evidence of a silk ear tube with potential for future clinical translation and OEM treatment.<\/jats:p>","DOI":"10.1002\/adhm.201801409","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T11:46:58Z","timestamp":1547034418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Silk Protein Bioresorbable, Drug\u2010Eluting Ear Tubes: Proof\u2010of\u2010Concept"],"prefix":"10.1002","volume":"8","author":[{"given":"Sarah A.","family":"Bradner","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Tufts University  Medford MA 02155 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Galaiya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhila","family":"Raol","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-7774","authenticated-orcid":false,"given":"David L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Tufts University  Medford MA 02155 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chistopher J.","family":"Hartnick","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Harvard Medical School  Boston MA 02114 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1177\/0194599812468849","volume":"149","author":"Rosenfeld R. 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