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To intervene in this pathological process, a new type of cardiac scaffold composed of a thermoset (poly\u2010[glycerol sebacate], PGS) and a thermoplastic (poly\u2010[\u03b5\u2010caprolactone], PCL) is directly printed by employing fused deposition modeling 3D\u2010printing technology. The PGS\u2010PCL scaffold possesses stacked construction with regular crisscrossed filaments and interconnected micropores and exhibits superior mechanical properties. In vitro studies demonstrate favorable biodegradability and biocompatibility of the PGS\u2010PCL scaffold. When implanted onto the infarcted myocardium, this scaffold improves and preserves heart function. Furthermore, the scaffold improves several vital aspects of myocardial remodeling. On the morphological level, the scaffold reduces ventricular wall thinning and attenuated infarct size, and on the cellular level, it enhances vascular density and increases M2 macrophage infiltration, which might further contribute to the mitigated myocardial apoptosis rate. Moreover, the flexible PGS\u2010PCL scaffold can be tailored to any desired shape, showing promise for annular\u2010shaped restraint device application and meeting the demands for minimal invasive operation. Overall, this study demonstrates the therapeutic effects and versatile applications of a novel 3D\u2010printed, biodegradable and biocompatible cardiac scaffold, which represents a promising strategy for improving myocardial remodeling after MI.<\/jats:p>","DOI":"10.1002\/adhm.201900065","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:01:02Z","timestamp":1554260462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Elastic 3D\u2010Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction"],"prefix":"10.1002","volume":"8","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai 200025 P. R. 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