{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:11:20Z","timestamp":1785363080137,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation plays a critical role in the development of hypoxia\u2013ischemia (HI) induced newborn brain damage. A localized, sustained delivery of dexamethasone (Dex) through an intracerebral injection could reduce the inflammatory response in the injured perinatal brain while avoiding unnecessary side effects. Herein, investigated using anionic sulfobutyl ether \u03b2\u2010cyclodextrin (SBE\u2010\u03b2\u2010CD) to load Dex in the (RADA)<jats:sub>4<\/jats:sub> nanofiber networks as a means of reducing the inflammatory response to HI injury is investigated. The ionic interaction between SBE\u2010\u03b2\u2010CD and (RADA)<jats:sub>4<\/jats:sub> dramatically affects nanofiber formation and the stability of the nanoscaffold is highly dependent on the SBE\u2010\u03b2\u2010CD\/(RADA)<jats:sub>4<\/jats:sub> ratio. It is observed that the Dex release rate is affected by the concentration of SBE\u2010\u03b2\u2010CD and (RADA)<jats:sub>4<\/jats:sub> peptide. A higher concentration of SBE\u2010\u03b2\u2010CD or (RADA)<jats:sub>4<\/jats:sub> results in a higher drug encapsulation efficiency and slower release rate of Dex. This phenomenon may be related to the structure of fiber bundles. Animal studies show that nanoscaffold loaded with Dex inhibits both microglia activation and glial scar formation compared to controls (Dex alone or nanoscaffold alone) within 2 days of injury. It is thought that this is a step toward building a multifaceted nanoscaffold that can be used to treat HI events in perinates.<\/jats:p>","DOI":"10.1002\/adhm.201900083","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T08:24:06Z","timestamp":1555057446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sustained Release of Dexamethasone from Sulfobutyl Ether \u03b2\u2010cyclodextrin Modified Self\u2010Assembling Peptide Nanoscaffolds in a Perinatal Rat Model of Hypoxia\u2013Ischemia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4984-9545","authenticated-orcid":false,"given":"Lei","family":"Lu","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu Sichuan 611756 China"},{"name":"Department of Chemical and Materials Engineering University of Alberta  Edmonton Alberta T6G 2V4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Neurosciences University of Alberta  Edmonton Alberta T6G 1C9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome Y.","family":"Yager","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Neurosciences University of Alberta  Edmonton Alberta T6G 1C9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Unsworth","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering University of Alberta  Edmonton Alberta T6G 2V4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1554"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00212-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20066"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2010.07.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.47"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v29.i4.40"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199610000-00015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3792-03.2004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20207"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.12.017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.053"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.08.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010115)63:2<109::AID-JNR1002>3.0.CO;2-J"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.052"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.03.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.02.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac200782h"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.09.018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC15551B"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200700033"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/b807155a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2nr00001f"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2013.04.019"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000190"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32910"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34804"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.02.001"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.09.037"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.08.026"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/b511336a"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21328"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S24038"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0381297"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001956"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200800860"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2005.11.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.05.012"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.01.007"},{"key":"e_1_2_8_42_1","unstructured":"R. C.Smith Massachusetts Institute of Technology 2010."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.07.046"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10359"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.09.020"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm800975j"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2012.694588"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.03.097"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.06.031"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(01)00128-X"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440070105"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fd62d2"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181fe3ec7"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602841103"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2003.12.008"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.988"},{"key":"e_1_2_8_57_1","volume-title":"Cyclodextrins and Their Inclusion Complexes","author":"Szejtli J.","year":"1982"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma502572w"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.009"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/b921448h"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3334"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.05.007"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2709-8"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2132-7"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.11.026"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.192535"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm401077b"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199310000-00029"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310141"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201900083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201900083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201900083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:25:29Z","timestamp":1759785929000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201900083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":71,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/adhm.201900083"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201900083","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"assertion":[{"value":"2019-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900083"}}