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In this context, the bone has a very complex architecture containing highly vascularized and calcified tissues, while cartilage is avascular and has low cellularity and few nutrients. Owing to this complexity, the repair and regeneration of these tissues are highly challenging. Identification of the appropriate biomaterial and fabrication technologies can provide sustainable solutions to this challenge. Here, nanosized Laponite<jats:sup>\u00ae<\/jats:sup> (Laponite is a trademark of the company BYK Additives Ltd.) has shown to be a promising material due to its unique properties such as excellent biocompatibility, facile gel formation, shear\u2010thinning property (reversible physical crosslinking), high specific surface area, degrade into nontoxic products, and with osteoinductive properties. Even though Laponite and Laponite\u2010based composite for 3D bioprinting application are considered as soft gels, they may therefore not be thought exhibiting sufficient mechanical strength for orthopedic applications. However, through the merging with suitable composite and, also by incorporation of crosslinking step, desired mechanical strength for orthopedic application can be obtained. In this review, recent advances and future perspective of bioprinting Laponite and Laponite composites for orthopedic applications are highlighted.<\/jats:p>","DOI":"10.1002\/adhm.201900158","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T05:58:14Z","timestamp":1554703094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bioprinting a Synthetic Smectic Clay for Orthopedic Applications"],"prefix":"10.1002","volume":"8","author":[{"given":"Samson","family":"Afewerki","sequence":"first","affiliation":[{"name":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  Cambridge MA 02139 USA"},{"name":"Harvard\u2010MIT Division of Health Science and Technology Massachusetts Institute of Technology  Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila S. S. 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