{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:47:24Z","timestamp":1783831644619,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS085568"],"award-info":[{"award-number":["R01NS085568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS091585"],"award-info":[{"award-number":["R01NS091585"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS099596"],"award-info":[{"award-number":["R01NS099596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX001473"],"award-info":[{"award-number":["RX001473"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS091585"],"award-info":[{"award-number":["R01NS091585"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stroke causes significant mortality and morbidity. Currently, there are no treatments which can regenerate brain tissue lost to infarction. Neural progenitor cells (NPCs) are at the forefront of preclinical studies for regenerative stroke therapies. NPCs can differentiate into and replace neurons and promote endogenous recovery mechanisms such as angiogenesis via trophic factor production and release. The stroke core is hypothetically the ideal location for replacement of neural tissue since it is in situ and develops into a potential space where injections may be targeted with minimal compression of healthy peri\u2010infarct tissue. However, the compromised perfusion and tissue degradation following ischemia create an inhospitable environment resistant to cellular therapy. Overcoming these limitations is critical to advancing cellular therapy. In this work, the therapeutic potential of mouse\u2010induced pluripotent stem cell derived NPCs is tested encapsulated in a basic fibroblast growth factor (bFGF) binding chondroitin sulfate\u2010A (CS\u2010A) hydrogel transplanted into the infarct core in a mouse sensorimotor cortex mini\u2010stroke model. It is shown that CS\u2010A encapsulation significantly improves vascular remodeling, cortical blood flow, and sensorimotor behavioral outcomes after stroke. It is found these improvements are negated by blocking bFGF, suggesting that the sustained trophic signaling endowed by the CS\u2010A hydrogel combined with NPC transplantation can promote tissue repair.<\/jats:p>","DOI":"10.1002\/adhm.201900285","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T12:17:07Z","timestamp":1579868227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Cortical Transplantation of Brain\u2010Mimetic Glycosaminoglycan Scaffolds and Neural Progenitor Cells Promotes Vascular Regeneration and Functional Recovery after Ischemic Stroke in Mice"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-7372","authenticated-orcid":false,"given":"Myles R.","family":"McCrary","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleena","family":"Jesson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Z.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Logun","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lenear","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Q.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lohitash","family":"Karumbaiah","sequence":"additional","affiliation":[{"name":"Regenerative Bioscience Center University of Georgia  Athens GA 30602 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"},{"name":"Center for Visual and Neurocognitive Rehabilitation Atlanta VA Medical Center  Decatur GA 30033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-2109","authenticated-orcid":false,"given":"Ling","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_4_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000366"},{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13522-w"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1802"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.003"},{"key":"e_1_2_4_3_3","doi-asserted-by":"publisher","DOI":"10.3727\/096368916X690403"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22180"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.22"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657251"},{"key":"e_1_2_4_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.011"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.028"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606471"},{"key":"e_1_2_4_6_3","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16649964"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000369610.76181.CF"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310361958"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2016.1094457"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0470-x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00805"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.04.021"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.5812\/archneurosci.25364"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.05.050"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.125"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.068"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/biom.23863"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.03.014"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-018-0083-8"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X684998"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.085"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20941"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000247888.25985.62"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2014.939172"},{"key":"e_1_2_4_20_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.015"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00397"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140815124447"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02871"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.309"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.298430"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.027"},{"key":"e_1_2_4_25_3","doi-asserted-by":"publisher","DOI":"10.2174\/187152410790780136"},{"key":"e_1_2_4_25_4","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13686"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.206630"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.004"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.240622"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.09.008"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0477-8"},{"key":"e_1_2_4_28_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3898"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.10.012"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381096"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17701460"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.03.006"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.11.004"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.009"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0957"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.15"},{"key":"e_1_2_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.002"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.8.1459"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00114-0"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.125"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.10.004"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.12.6967"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.201900285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201900285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.201900285","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.201900285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:14:49Z","timestamp":1759763689000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.201900285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,24]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/adhm.201900285"],"URL":"https:\/\/doi.org\/10.1002\/adhm.201900285","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,24]]},"assertion":[{"value":"2019-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900285"}}