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Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, but remains a challenge. Here, a microscaffold cochlear electrode array (MiSCEA) consisting of a microfabricated flexible electrode array and a 3D microscaffold for steroid reservoir is reported. The MiSCEA without loaded drug is tested by measuring the electrically evoked auditory brainstem response of the cochlea in guinea pigs (<jats:italic>n<\/jats:italic> = 4). The scaffold is then coated with steroid (dexamethasone) encapsulated in polylactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid and the continuous release of the steroid into artificial perilymph during six weeks is monitored. The steroid\u2010containing scaffolds are then implanted into guinea pigs (<jats:italic>n<\/jats:italic> = 4) and threshold shifts are analyzed for four weeks by measuring the acoustically evoked auditory brainstem response. The threshold shifts tend to be lower in the group implanted with the steroid\u2010containing MiSCEAs. The feasibility of 3D MiSCEA opens up the development of potential next\u2010generation cochlear electrode with improved steroid release dynamics into cochlea.<\/jats:p>","DOI":"10.1002\/adhm.201900379","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T16:31:35Z","timestamp":1568824295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A 3D Microscaffold Cochlear Electrode Array for Steroid Elution"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-0996","authenticated-orcid":false,"given":"Jongmoon","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 Republic of Korea"},{"name":"DGIST\u2010ETH Microrobot Research Center DGIST  Daegu 42988 Republic of Korea"},{"name":"Microsystem Laboratory \u00c9cole Polytechnique 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