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However, it is dramatically underutilized due to the inability to test clozapine blood levels in finger\u2010pricked patients' samples. This prevents obtaining immediate blood levels information, resulting in suboptimal treatment. The development of an electrochemical microsensor is presented, which enables, for the first time, clozapine detection in microliters volume whole blood. The sensor is based on a microelectrode modified with micrometer\u2010thick biopolymer chitosan encapsulating carbon nanotubes. The developed sensor detects clozapine oxidation current, in the presence of other electroactive species in the blood, which generate overlapping electrochemical signals. Clozapine detection, characterized in whole blood from healthy volunteers, displays a sensitivity of 32 \u00b1 3.0 \u00b5A cm<jats:sup>\u22122<\/jats:sup> \u00b5mol<jats:sup>\u22121<\/jats:sup> L and a limit\u2010of\u2010detection of 0.5 \u00b1 0.03 \u00b5mol L<jats:sup>\u22121<\/jats:sup>. Finally, the developed sensor displays a reproducible electrochemical signal (0.6% relative standard deviation) and high storage stability (9.8% relative standard deviation after 8 days) in serum samples and high repeatability (9% relative standard deviation for the 5th repetition) in whole blood samples. By enabling the rapid and minimally invasive clozapine detection at the point\u2010of\u2010care, an optimal schizophrenia treatment is provided.<\/jats:p>","DOI":"10.1002\/adhm.201900462","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T04:16:28Z","timestamp":1561522588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Chitosan\u2013Carbon Nanotube\u2010Modified Microelectrode for In Situ Detection of Blood Levels of the Antipsychotic Clozapine in a Finger\u2010Pricked Sample Volume"],"prefix":"10.1002","volume":"8","author":[{"given":"Rajendra P.","family":"Shukla","sequence":"first","affiliation":[{"name":"Nanobioelectronics Laboratory Department of Biomedical Engineering Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 8410501 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-0440","authenticated-orcid":false,"given":"Hadar","family":"Ben\u2010Yoav","sequence":"additional","affiliation":[{"name":"Nanobioelectronics Laboratory Department of Biomedical Engineering Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 8410501 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2016.14.4.323"},{"key":"e_1_2_7_2_1","unstructured":"U.S. Food & Drug Administration https:\/\/www.fda.gov\/drugs\/drugsafety\/postmarketdrugsafetyinformationforpatientsandproviders\/ucm497790.htm(accessed: April2019)."},{"key":"e_1_2_7_3_1","first-page":"1","volume":"18","author":"Iqbal M. 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