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Constructing a functional and confluent layer of endothelial cells (ECs) is considered an ideal method to prevent these problems. However, oxidative stress induced by the disease and implantation can damage ECs and hinder the endothelialization of implants. Thus, developing biomaterials that can protect ECs adhesion and proliferation from oxidative stress is urgently needed for the rapid endothelialization of vascular implants. In this work, a novel polyurethane (PU\u2010TBN) is synthesized by employing tetramethylpyrazine\u2010nitrone (TBN) as end\u2010group to endow polymers with dual functions of antioxidant activity and promoting endothelialization. Common PU without TBN is also prepared to be control. Compared to PU, PU\u2010TBN significantly promotes human umbilical vein endothelial cells (HUVECs) adhesion and proliferation, where cells spread well and a confluent endothelial layer is formed. PU\u2010TBN also shows obvious free radical scavenging activity, and thus effectively attenuates oxidative stress to protect HUVECs from oxidative apoptosis. Moreover, PU\u2010TBN exhibits enhanced antiplatelets effect, excellent biocompatibility, and similar mechanical properties to PU. These characteristics can endow PU\u2010TBN with great potential to be used as vascular implants or coatings of other materials for rapid endothelialization under complex oxidative stress environment.<\/jats:p>","DOI":"10.1002\/adhm.201900582","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T10:08:52Z","timestamp":1568714932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polyurethane End\u2010Capped by Tetramethylpyrazine\u2010Nitrone for Promoting Endothelialization Under Oxidative Stress"],"prefix":"10.1002","volume":"8","author":[{"given":"Baoliu","family":"Qu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  5625 Renmin Stree Changchun 130022 P. R. 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