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In particular, cardiac patches generally provide a cursory level of cell attachment due to the lack of an adequate microenvironment. From this perspective, decellularized cell\u2010derived ECM (CDM) is attractive in its recapitulation of a natural biophysical environment for cells. Unfortunately, its weak physical property renders it difficult to retain in its original form, limiting its full potential. Here, a novel strategy to peel CDM off from its underlying substrate is proposed. By physically stamping it onto a polyvinyl alcohol hydrogel, the resulting stretchable extracellular matrix (ECM) membrane preserves the natural microenvironment of CDM, thereby conferring a biological interface to a viscoelastic membrane. Its various mechanical and biological properties are characterized and its capacity to improve cardiomyocyte functionality is demonstrated. Finally, evidence of enhanced stem cell delivery using the stretchable ECM membrane is presented, which leads to improved cardiac remodeling in a rat MI model. A new class of material based on natural CDM is envisioned for the enhanced delivery of cells and growth factors that have a known affinity with ECM.<\/jats:p>","DOI":"10.1002\/adhm.201900593","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T04:45:49Z","timestamp":1563165949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Stretchable ECM Patch Enhances Stem Cell Delivery for Post\u2010MI Cardiovascular Repair"],"prefix":"10.1002","volume":"8","author":[{"given":"In Gul","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Biomaterials Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Seoul National University Hospital  Seoul 03080 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintai 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