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This coating is non\u2010bioresorbable and follows the architecture of the mesh without impeding connective tissue integration. Following implantation, the tissue response is biased toward vascularization instead of fibrosis. The vessel density around the MAA mesh is double that of the uncoated mesh two weeks after implantation. This initial vasculature regresses after two weeks while mature vessels remain, suggesting an enhanced healing response. Concurrently, the MAA coating alters the foreign body response to the mesh. Fewer infiltrating cells, macrophages, and foreign body giant cells are found at the tissue\u2013material interface three weeks after implantation. The coating also dampens inflammation, with lower expression levels of pro\u2010inflammatory and fibrogenic signals (e.g., <jats:italic>Tgf\u2010\u03b21<\/jats:italic>, <jats:italic>Tnf\u2010\u03b1<\/jats:italic>, and <jats:italic>Il1\u2010\u03b2<\/jats:italic>) and similar expression levels of anti\u2010inflammatory cytokines (e.g., <jats:italic>Il10<\/jats:italic> and <jats:italic>Il6<\/jats:italic>) compared to the uncoated mesh. Contrary to other coatings that aim to mitigate the foreign body response to PP mesh, a MAA coating does not require the addition of any biological agents to have an effect, making the coated mesh an attractive candidate for soft tissue repair.<\/jats:p>","DOI":"10.1002\/adhm.201900667","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T03:46:07Z","timestamp":1565667967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Methacrylic Acid Copolymer Coating Enhances Constructive Remodeling of Polypropylene Mesh by Increasing the Vascular Response"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6711-2686","authenticated-orcid":false,"given":"Virginie F.","family":"Coindre","sequence":"first","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  160 College Street, Suite 406 Toronto Ontario M5S 3G9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda M.","family":"Carleton","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  160 College Street, Suite 406 Toronto Ontario M5S 3G9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-6732","authenticated-orcid":false,"given":"Michael V.","family":"Sefton","sequence":"additional","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  160 College Street, Suite 406 Toronto Ontario M5S 3G9 Canada"},{"name":"Department of Chemical Engineering and Applied Chemistry University of Toronto  160 College Street, Suite 406 Toronto Ontario M5S 3G9 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12020"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318195888d"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31596-3"},{"key":"e_1_2_8_4_1","volume-title":"FDA News Released","author":"Food and Drug Administration","year":"2011"},{"key":"e_1_2_8_5_1","volume-title":"FDA News Release","author":"Food and Drug Administration","year":"2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/11024159950189726"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.04.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35958"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/968087"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.02.045"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0001-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-4764-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33136"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0722-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2283-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.019"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-4049-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00211-7"},{"key":"e_1_2_8_20_1","first-page":"484","volume":"93","author":"Martin D. 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