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Miniaturization of this technology is crucial and will provide several advantages, ranging from better spatiotemporal control of delivery to reduced invasiveness for implanted OEIPs. To miniaturize OEIPs, new configurations have been developed based on glass capillary fibers filled with an anion exchange membrane (AEM). Fiber capillary OEIPs can be easily implanted in proximity to targeted cells and tissues. Herein, the efficacy of such a fiber capillary OEIP for modulation of inflammation in human monocytes is demonstrated. The devices are located on inflammatory monocytes and local delivery of salicylic acid (SA) is initiated. Highly localized SA delivery results in a significant decrease in cytokine (tumor necrosis factor alpha and interleukin 6) levels after lipopolysaccharide stimulation. The findings\u2014the first use of such capillary OEIPs in mammalian cells or systems\u2014demonstrate the utility of the technology for optimizing transport and delivery of different therapeutic substances at low concentrations, with the benefit of local and controlled administration that limits the adverse effect of oral\/systemic drug delivery.<\/jats:p>","DOI":"10.1002\/adhm.201900813","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T05:48:41Z","timestamp":1568094521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Modulating Inflammation in Monocytes Using Capillary Fiber Organic Electronic Ion Pumps"],"prefix":"10.1002","volume":"8","author":[{"given":"Maria","family":"Seitanidou","sequence":"first","affiliation":[{"name":"Laboratory of Organic Electronics Department of Science and Technology Link\u00f6ping University  60174 Norrk\u00f6ping 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