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Here, a multistimuli\u2010responsive hydrogel with potent antibacterial activity by a combination of supramolecular assembly and iminoboronate chemistry is reported. The hydrogel consists of all\u2010small\u2010molecule building blocks including aminoglycoside, guanosine, potassium ion, and a bifunctional anchor bearing both boronic acid and aldehyde groups. Guanosines form quadruplexes in the presence of potassium ions via supramolecular assembly, and the bifunctional anchor connects aminoglycosides, a class of potent antibiotics to cis\u2010diol groups on quadruplexes via dynamic iminoboronate chemistry, yielding a smart hydrogel containing abundant antibiotics. The hydrogel is sensitive to multistimuli such as heat, acids, oxidants, glucose and crown ether, which promote the release of antibiotics from the gels. Moreover, the prepared hydrogels show potent antibacterial activities both in vitro and in vivo. The results provide a new option to prepare antibacterial hydrogels with multistimuli responsiveness via facile chemistry using all\u2010small\u2010molecule building blocks.<\/jats:p>","DOI":"10.1002\/adhm.201901329","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T03:19:35Z","timestamp":1575861575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Stimuli\u2010Responsive Hydrogels with Antibacterial Activity Assembled from Guanosine, Aminoglycoside, and a Bifunctional Anchor"],"prefix":"10.1002","volume":"9","author":[{"given":"Jingjing","family":"Hu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University  Shanghai 200241 P. R. 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