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Hereby, a mechanically tough and bioactive hydrogel based on autologous injectable platelet\u2010rich fibrin (iPRF) modified with gelatin nanoparticles (GNPs) is developed. This composite hydrogel demonstrates a double network (DN) mechanism, wherein covalent network of fibrin serves to maintain material integrity, and self\u2010assembled colloidal network of GNPs dissipates force upon loading. A rabbit sinus augmentation model is used to investigate the bioactivity and osteogenesis capacity of the DN hydrogels. The DN hydrogels adapt to the local environmental complexity of bone defects, i.e., accommodate the irregular shape of the defects and withstand the pressure formed in the maxillary sinus during animal's respiration process. The DN hydrogel is also demonstrated to absorb and prolong the release of the bioactive growth factors stemming from iPRF, which could have contributed to the early angiogenesis and osteogenesis observed inside the sinus. This adaptable and bioactive DN hydrogel can achieve enhanced bone regeneration in treating complex bone defects by maintaining long\u2010term bone mass and withstanding the functional mechanical stimuli.<\/jats:p>","DOI":"10.1002\/adhm.201901469","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T03:58:20Z","timestamp":1580270300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Gelatin Nanoparticle\u2010Injectable Platelet\u2010Rich Fibrin Double Network Hydrogels with Local Adaptability and Bioactivity for Enhanced Osteogenesis"],"prefix":"10.1002","volume":"9","author":[{"given":"Zhixiang","family":"Mu","sequence":"first","affiliation":[{"name":"Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Medical University  Chongqing 401147 P. R. 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