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The challenge for such systems is to achieve directional and precise delivery in inaccessible narrow lesions, such as periodontal pockets or root canals in deeper portions of the dentinal tubules. The primary strategy to tackle this challenge is fabricating a smart tracking delivery system. Here, drug\u2010loaded biodegradable micromotors showing self\u2010propelled directional movement along a hydrogen peroxide concentration gradient produced by phorbol esters\u2010stimulated macrophages are reported. The drug\u2010loaded poly(lactic\u2010co\u2010glycolic acid) micromotors with asymmetric coverage of enzyme (patch\u2010like enzyme distribution) are prepared by electrospraying and postfunctionalized with catalase via 1\u2010ethyl\u20103\u2010(3\u2010dimethylaminopropyl) carbodiimide coupling. Doxycycline, a common drug for the treatment of periodontal disease, is selected as a model drug, and the release study by high\u2010performance liquid chromatography is shown that both the postfunctionalization step and the presence of hydrogen peroxide have no negative influence on drug release profiles. The movement behavior in the presence of hydrogen peroxide is confirmed by nanoparticle tracking analysis. An in vitro model is designed and confirmed the response efficiency and directional control of the micromotors toward phorbol esters\u2010stimulated macrophages.<\/jats:p>","DOI":"10.1002\/adhm.201901710","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T08:36:14Z","timestamp":1583483774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Self\u2010Propelled PLGA Micromotor with Chemotactic Response to Inflammation"],"prefix":"10.1002","volume":"9","author":[{"given":"Jiamian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dentistry \u2013 Biomaterials Radboud University Medical Center  6525 EX Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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