{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:47:05Z","timestamp":1791726425783,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771027"],"award-info":[{"award-number":["31771027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a great challenge in regenerating osteochondral defects because they involve lesions of both cartilage and subchondral bone, which have remarkable differences in their chemical compositions and biological lineages. Thus, considering the complicated requirements in osteochondral reconstruction, a biomimetic biphasic osteochondral scaffold (BBOS) with the layer\u2010specific release of stem cell differentiation inducers are developed. The cartilage regeneration layer (cartilage scaffold, CS) in the BBOS contains a hyaluronic acid hydrogel to mimic the composition of cartilage, which is mechanically enhanced by host\u2013guest supramolecular units to control the release of kartogenin (KGN). Additionally, a 3D\u2010printed hydroxyapatite (HAp) scaffold releasing alendronate (ALN) is employed as the bone\u2010regeneration layer (bone scaffold, BS). The two layers are bound by semi\u2010immersion and could regulate the hierarchical targeted differentiation behavior of the stem cells. Compared to the drug\u2010free scaffold, the MSCs in the BBOS could be promoted to differentiate into both chondrocytes and osteoblasts. The in vivo results demonstrate the strong promotion of cartilage or bone regeneration in their respective layers. It is expected that this BBOS with layer\u2010specific inducer release can become a new strategy for osteochondral regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202000076","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T03:46:46Z","timestamp":1587959206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["A Biomimetic Biphasic Osteochondral Scaffold with Layer\u2010Specific Release of Stem Cell Differentiation Inducers for the Reconstruction of Osteochondral Defects"],"prefix":"10.1002","volume":"9","author":[{"given":"Xuemin","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkai","family":"Xuan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Engineering of Guangdong Province South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Institute Peking University  Shenzhen 518055 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