{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:58Z","timestamp":1791246178257,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870982"],"award-info":[{"award-number":["81870982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8157118"],"award-info":[{"award-number":["8157118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371354"],"award-info":[{"award-number":["81371354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030312009"],"award-info":[{"award-number":["2017A030312009"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>At present, reconnecting the transected nerve in clinic is still mainly reliant on surgery suture. This is a procedure that requires thorough training and is also time consuming. Here, an octa\u2010poly(ethylene glycol) (PEG)\u2010based adhesive for fast reconnecting of the transected peripheral nerve is reported. To enhance the therapeutic efficacy, a succinyl unit is applied to endow the controllably dissolvable property of the adhesive, and lithium is loaded in the adhesive to improve the axonal regeneration. Present data reveal that this adhesive possesses good cytocompatibility and can significantly shorten the reconnecting time of the transected nerve ends compared to that required for suture surgery. Histology, electrophysiological, and behavior assessments indicate that the adhesive reconnected nerves exhibit a low grade of fibrosis, inflammation response, and myoatrophy as well as robust axonal regeneration and functional recovery. Together, these results indicate that this octa\u2010PEG adhesive can act as an alternative to traditional nerve suture in peripheral nerve injury.<\/jats:p>","DOI":"10.1002\/adhm.202000268","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T03:49:11Z","timestamp":1589946551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lithium Loaded Octa\u2010Poly(Ethylene Glycol) Based Adhesive Facilitates Axon Regeneration and Reconnection of Transected Peripheral Nerves"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0987-8453","authenticated-orcid":false,"given":"Yazhong","family":"Bu","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"},{"name":"Guangzhou Regenerative Medicine and Health Guangdong Laboratory  Guangzhou 510530 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhua","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-2903","authenticated-orcid":false,"given":"Jiasong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Southern Medical University  Guangzhou 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University  Guangzhou 510515 China"},{"name":"Guangzhou Regenerative Medicine and Health Guangdong Laboratory  Guangzhou 510530 China"},{"name":"Key Laboratory of Mental Health of the Ministry of Education Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Center for Brain Science and Brain\u2010Inspired Intelligence Guangdong Province Key Laboratory of Psychiatric Disorders  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004121"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.243701"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.147944"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201702170"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15807"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001566"},{"key":"e_1_2_7_7_1","first-page":"291809110","author":"Deng J.","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201970202"},{"key":"e_1_2_7_9_1","first-page":"160","volume":"07","author":"Koulaxouzidis G.","year":"2015","journal-title":"Neural Regener. Res."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB20696C"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00312B"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37186"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201202365"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.027"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.069"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.055"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.10.017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901580"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1242\/jcs.88.3.389","volume":"88","author":"Ahkong Q. F.","year":"1987","journal-title":"J. Cell Sci."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.251336"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23023"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.241473"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31829588cf"},{"key":"e_1_2_7_24_1","first-page":"5410","volume":"8","author":"Chen Y.","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604827"},{"key":"e_1_2_7_27_1","first-page":"658753","author":"Su H.","year":"2014","journal-title":"Biomed Res. Int."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(97)00327-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S221625"},{"key":"e_1_2_7_30_1","first-page":"55","volume":"13","author":"Bittner G. D.","year":"2018","journal-title":"Neural Regener. Res."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801555"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.10.020"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.03.006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24244615"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1489381"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918777614"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.12.013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.033"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.068"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00437"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.03.005"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2012.08.009"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00108"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198901000-00024"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-018-2041-9"},{"key":"e_1_2_7_46_1","first-page":"75","volume":"12","author":"Masson P.","year":"1929","journal-title":"J. Tech. Methods"},{"key":"e_1_2_7_47_1","volume-title":"Histopathologic Methods and Color Atlas of Special Stains and Tissue Artifacts","author":"Luna L. G.","year":"1992"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25187"},{"key":"e_1_2_7_49_1","first-page":"2362","volume":"10","author":"Wang Z.","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.5.1769"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-006-9067-4"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadhm.202000268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202000268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202000268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202000268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T16:57:49Z","timestamp":1759769869000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202000268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":51,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/adhm.202000268"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202000268","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"2020-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000268"}}