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However, there are only few reports describing their use in animal cell culture and tissue transplantation. In this study, onion epithelial membranes (OEM) is used as scaffolds to support cultures of a variety of cells such as fibroblasts and epithelial cells notably; they maintain the phenotypic characteristics of corneal epithelial cells. This improvement includes preservation of the proliferative potential and stemness of rabbit corneal epithelial cells (RCECs). Such an outcome suggests that this cost\u2010effective technology warrants further evaluation to determine if OEM is a viable candidate for use as scaffolds in corneal epithelial transplantation surgery. To test this possibility, rabbit corneal epithelial cells expanded on OEM are transplanted to treat corneal epithelial defects in limbal stem cell deficient rabbits. This procedure is successful because it shortens the time required for wound healing to restore losses in corneal epithelial integrity, and forms a more compact and stratified epithelium framework than the untreated group. Ultimately, should they be proven to be effective in other relevant animal model systems, their usefulness for treating wounds in a clinical setting warrants consideration.<\/jats:p>","DOI":"10.1002\/adhm.202000469","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:07:43Z","timestamp":1592359663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery"],"prefix":"10.1002","volume":"9","author":[{"given":"Guoliang","family":"Wang","sequence":"first","affiliation":[{"name":"Eye Institute &amp; Affiliated Xiamen Eye Center School of Medicine Xiamen University  Xiamen Fujian 361102 China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science  Xiamen Fujian 361102 China"},{"name":"School of Pharmaceutical Sciences Xiamen University  Xiamen Fujian 361102 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute &amp; 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