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This strategy is particularly beneficial in the management of inflammatory bowel disease (IBD). Here an inflammation\u2010targeting (IT) approach based on heparin\u2010coated human serum albumin nanoparticles (HEP\u2010HSA NPs) that utilize the increased intestinal permeability and changes in electrostatic interaction at the site of intestinal inflammation is described. Using small\u2010molecule and biologic drugs as a model for drug combination, the HEP\u2010HSA NPs demonstrate the capacity to load both drugs simultaneously; the dual\u2010drug loaded HEP\u2010HSA NPs exhibit a higher anti\u2010inflammatory effect than both of the single\u2010drug loaded NPs in vitro and selectively bind to inflamed intestine after enema administration in vivo in a murine model of colitis. Importantly, analyses of the physicochemical characteristics and targeting capacities of these NPs indicate that HEP coating modulates NP binding to the inflamed intestine, providing a foundation for future IT\u2010NP formulation development.<\/jats:p>","DOI":"10.1002\/adhm.202000536","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T08:04:37Z","timestamp":1593417877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Heparin\u2010Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine"],"prefix":"10.1002","volume":"9","author":[{"given":"Sufeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy Department of Medicine Brigham and Women's Hospital  Boston MA 02115 USA"},{"name":"Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology  Cambridge MA 02139 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