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The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity, drag, and inertial impaction. Addition of an electrical force to aerosol particles, exerted by an electrostatic field, can improve spatial aerosol homogeneity and enhance tissue penetration. A computational fluid dynamics model shows that electrostatic precipitation (EP) results in a significantly improved aerosol distribution. Fluorescent nanoparticles (NPs) remain stable after nebulization in vitro, while EP significantly improves spatial homogeneity of NP distribution. Next, pressurized intraperitoneal chemotherapy with and without EP using NP albumin bound paclitaxel (Nab\u2010PTX) in a novel rat model is examined. EP does not worsen the effects of CO<jats:sub>2<\/jats:sub> insufflation and intraperitoneal Nab\u2010PTX on mesothelial structural integrity or the severity of peritoneal inflammation. Importantly, EP significantly enhances tissue penetration of Nab\u2010PTX in the anatomical regions not facing the nozzle of the nebulizer. Also, the addition of EP leads to more homogenous peritoneal tissue concentrations of Nab\u2010PTX, in parallel with higher plasma concentrations. In conclusion, EP enhances spatial homogeneity and tissue uptake after intraperitoneal nebulization of anticancer NPs.<\/jats:p>","DOI":"10.1002\/adhm.202000655","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:13:34Z","timestamp":1592360014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles: Proof of Concept and Preclinical Validation"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-8104","authenticated-orcid":false,"given":"Leen","family":"Van de Sande","sequence":"first","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Corneel Heymanslaan 10 Ghent 9000 Belgium"},{"name":"Cancer Research Institute Ghent (CRIG) Ghent University  Corneel Heymanslaan 10 Ghent 9000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Rahimi\u2010Gorji","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Corneel Heymanslaan 10 Ghent 9000 Belgium"},{"name":"Cancer Research Institute Ghent (CRIG) Ghent University  Corneel Heymanslaan 10 Ghent 9000 Belgium"},{"name":"IBiTech \u2013 bioMMeda Ghent University  Corneel Heymanslaan 10 Ghent 9000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Laboratory Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Via Mario Negri 2 Milan 20156 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Davoli","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Laboratory Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Via Mario Negri 2 Milan 20156 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Matteo","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Laboratory Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Via Mario Negri 2 Milan 20156 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6nke","family":"Detlefsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  J.B. 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