{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:52:41Z","timestamp":1790686361790,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To solve the problem of vascular access failure, a novel semi\u2010degradable hybrid vascular graft, manufactured by electrospinning using silk fibroin and polyurethane (Silkothane), has been previously developed and characterized in vitro. This proof\u2010of\u2010concept animal study aims at evaluating the performances of Silkothane grafts in a sheep model of arteriovenous shunt, in terms of patency and short\u2010term remodeling. Nine Silkothane grafts are implanted between the common carotid artery and the external jugular vein of nine sheep, examined by palpation three times per week, by echo\u2010color Doppler every two weeks, and euthanized at 30, 60, and 90 days (<jats:italic>N<\/jats:italic> = 3 per group). At sacrifice, grafts are harvested and submitted for histopathology and\/or scanning electron microcopy (SEM). No cases of graft\u2010related complications are recorded. Eight of nine sheep (89%) show 100% primary unassisted patency at the respective time of sacrifice (flow rate 1.76\u00a0\u00b1\u00a00.61\u00a0L min<jats:sup>\u22121<\/jats:sup>, one case of surgery\u2010related thrombosis excluded). Histopathology and SEM analysis evidence signs of inflammation and pseudointima inside the graft lumen, especially at the venous anastomosis; however, endoluminal stenosis never impairs the functionality of the shunt and coverage by endothelial cells is observed. In this model, Silkothane grafts grant safety and 100% patency up to 90 days.<\/jats:p>","DOI":"10.1002\/adhm.202000794","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T03:45:47Z","timestamp":1600141547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Novel Hybrid Silk Fibroin\/Polyurethane Arteriovenous Graft for Hemodialysis: Proof\u2010of\u2010Concept Animal Study in an Ovine Model"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-6249","authenticated-orcid":false,"given":"Stefania Adele","family":"Riboldi","sequence":"first","affiliation":[{"name":"Bioengineering Laboratories S.r.l.  Cant\u00f9 22063 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Tozzi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Universit\u00e0 degli Studi dell'Insubria  Varese 21100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Bagardi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Universit\u00e0 degli Studi di Milano  Milano 20122 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Ravasio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Universit\u00e0 degli Studi di Milano  Milano 20122 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Cigalino","sequence":"additional","affiliation":[{"name":"Centre for Clinical Veterinary Medicine and Experimental Zootechnics Universit\u00e0 degli Studi di Milano  Milano 20122 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Universit\u00e0 degli Studi di Milano Bicocca  Milano 20126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Universit\u00e0 degli Studi dell'Insubria  Varese 21100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Nahal","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Universit\u00e0 degli Studi dell'Insubria  Varese 21100 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Spandri","sequence":"additional","affiliation":[{"name":"Bioengineering Laboratories S.r.l.  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Cant\u00f9 22063 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Department of Management, Information and Production Engineering Universit\u00e0 degli Studi di Bergamo  Bergamo 24129 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Acocella","sequence":"additional","affiliation":[{"name":"Department of Health, Animal Science and Food Safety Universit\u00e0 degli Studi di Milano  Milano 20122 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_8_1_1","volume-title":"Hemodialysis Access. Fundamentals and Advanced Management","author":"Cormack F. C.","year":"2017"},{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1129729818776571","volume":"20","author":"Al Shakarchi J.","year":"2019","journal-title":"J. Vasc. 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