{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:23:05Z","timestamp":1775190185350,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200734"],"award-info":[{"award-number":["81200734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS). However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. In this study, a new polyethylene glycol hydrogel (PEG\u2010H) treatment model is developed to achieve sustained release of drugs at the locality while avoiding those adverse effects. The PEG\u2010H is composed of 4\u2010arm\u2010PEG\u2010SH and silver ions through a high affinity and dynamic reversible coordination bond between the thiol and silver ion. In the initial test, PEG\u2010H is loaded with Clarithromycin (CAM\u2010Lips@Hydrogel) or Clarithromycin and Budesonide liposomes (CAM+BUD\u2010Lips@Hydrogel). The results show that PEG\u2010H maintains the characteristics of self\u2010healing, biodegradability, moderate swelling rate, injectibility and sustained drug release. In in vivo studies, the hydrogel is injected into the maxillary sinus of ABRS rabbit models. In both a single or combined load, the hydrogel not only plays an effective role as an anti\u2010bacterial, but also inhibits inflammatory response of local sinus mucosa. In addition, no other side effects are observed in the ABRS rabbit model through behavioral observation and drug sensitivity tests. Therefore, the injectable self\u2010healing hydrogel with anti\u2010bacterial and anti\u2010inflammatory properties provides a new micro invasive therapeutic method for the clinical treatment of ABRS.<\/jats:p>","DOI":"10.1002\/adhm.202001032","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T03:04:14Z","timestamp":1601175854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Injectable and Self\u2010Healing Hydrogel with Anti\u2010Bacterial and Anti\u2010Inflammatory Properties for Acute Bacterial Rhinosinusitis with Micro Invasive Treatment"],"prefix":"10.1002","volume":"9","author":[{"given":"Zhengming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-054X","authenticated-orcid":false,"given":"Zhengwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianmin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanghua","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery of Changhai Hospital Naval Military Medical University (The Second Military Medical University)  168 Changhai Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"1","volume":"260","author":"Blackwell D. L.","year":"2014","journal-title":"Vital. Health. Stat."},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.401"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192330"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2354"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010101"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815572097"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp20X708821"},{"key":"e_1_2_7_7_1","first-page":"CD006089","volume":"9","author":"Lemiengre M. B.","year":"2018","journal-title":"Cochrane. Database Syst. Rev."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(03)00155-5"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/522763"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir940"},{"key":"e_1_2_7_9_1","first-page":"CD000243","volume":"11","author":"Ahovuo\u2010Saloranta A.","year":"2014","journal-title":"Cochrane. Database Syst. Rev."},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.PEDS10504"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30414-6"},{"key":"e_1_2_7_10_3","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw065"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937050-00003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00022"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.233932"},{"key":"e_1_2_7_12_3","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206067"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.018"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01198-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202001196"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201704039"},{"key":"e_1_2_7_14_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.9b00706"},{"key":"e_1_2_7_14_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816ba576"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2274"},{"key":"e_1_2_7_15_3","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4237"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.06.036"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.031"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41427-019-0185-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.12.005"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00024-13"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.173"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku385"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401413"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis651"},{"key":"e_1_2_7_21_3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00224-15"},{"key":"e_1_2_7_21_4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03102"},{"key":"e_1_2_7_21_5","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1081-8"},{"key":"e_1_2_7_22_1","first-page":"CD008115","volume":"25","author":"Venekamp R. P.","year":"2014","journal-title":"Cochrane. Database Syst. Rev."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1043"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1901239"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1105"},{"key":"e_1_2_7_24_3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.037"},{"key":"e_1_2_7_24_4","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191012"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202001032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202001032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202001032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:41:42Z","timestamp":1759783302000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202001032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":47,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/adhm.202001032"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202001032","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2001032"}}