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However, these sensors typically become encapsulated after implantation, and the dynamic range decreases following long\u2010term implantation and use. Herein, a four\u2010arm polyethylene glycol (PEG) hydrogel is developed with an immobilized glucose\u2010responsive fluorescence dye (GF\u2010PEG\u2010gel); this hydrogel is effective in mitigating foreign body reactions (FBRs) that hinder stable glucose responses in vivo. The GF\u2010PEG\u2010gel attached to an implantable device successfully traces blood glucose concentrations in diabetic model rats for 45 days. A pig experiment shows that the device measures the glucose concentration with an equivalent accuracy to that required for clinically available settings.<\/jats:p>","DOI":"10.1002\/adhm.202001286","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T03:57:39Z","timestamp":1605499059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Long\u2010Term Continuous Glucose Monitoring Using a Fluorescence\u2010Based Biocompatible Hydrogel Glucose Sensor"],"prefix":"10.1002","volume":"10","author":[{"given":"Jun","family":"Sawayama","sequence":"first","affiliation":[{"name":"Institute of Industrial Science The University of Tokyo  4\u20106\u20101 Komaba Meguro\u2010ku Tokyo 153\u20108505 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-0409","authenticated-orcid":false,"given":"Shoji","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Institute of Industrial Science The University of Tokyo  4\u20106\u20101 Komaba Meguro\u2010ku Tokyo 153\u20108505 Japan"},{"name":"Graduate School of Information Science and Technology The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108656 Japan"},{"name":"International Research Center for Neurointelligence (WPI\u2010IRCN) The University of Tokyo Institutes for Advanced Study The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20108656 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1231"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0273-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700428"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0956-5663(92)87013-F"},{"key":"e_1_2_5_7_1","volume-title":"Role of Continuous Glucose Monitoring in Diabetes Treatment","year":"2018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios3040400"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34424"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0020"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000056873.87165.5A"},{"key":"e_1_2_5_12_1","first-page":"S68","volume":"34","author":"Christensen L. 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