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In this work, a therapeutic strategy using graphene nanoribbons (GNR) functionalized with 4\u2010arm polyethylene glycol (PEG) and chlorin e6 (Ce6), a sonosensitizer, to target metastatic ovarian cancer spheroids is reported. GNR\u2010PEG\u2010Ce6 adsorbs onto the spheroids and disrupts their adhesion to extracellular matrix proteins or LP\u20109 mesothelial cells. Furthermore, for spheroids that do adhere, GNR\u2010PEG\u2010Ce6 delays spheroid disaggregation and spreading as well as mesothelial clearance, key metastatic processes following adhesion. Owing to the sonodynamic effects of Ce6 and its localized delivery via the biomaterial, GNR\u2010PEG\u2010Ce6 can kill ovarian cancer spheroids adhered to LP\u20109 cell monolayers when combined with mild ultrasound irradiation. The interaction with GNR\u2010PEG\u2010Ce6 also loosens cell\u2013cell adhesions within the spheroids, rendering them more susceptible to treatment with the chemotherapeutic agents cisplatin and paclitaxel, which typically have difficulty in penetrating ovarian cancer spheroids. Thus, this material can facilitate effective chemotherapeutic and sonodynamic combination therapies. Finally, the adhesion inhibiting and sonodynamic effects of GNR\u2010PEG\u2010Ce6 are also validated with tumor spheroids derived from the ascites fluid of ovarian cancer patients, providing evidence of the translational potential of this biomaterial approach.<\/jats:p>","DOI":"10.1002\/adhm.202001368","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T10:15:39Z","timestamp":1622283339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Sonosensitizer\u2010Functionalized Graphene Nanoribbons for Adhesion Blocking and Sonodynamic Ablation of Ovarian Cancer Spheroids"],"prefix":"10.1002","volume":"10","author":[{"given":"Hak Rae","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Materials Science University of Minnesota  Minneapolis MN 55455 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae 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