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Significant barriers exist to improving vaccine coverage in lower\u2010 and middle\u2010income countries, including the costly requirements for cold\u2010chain distribution and trained medical personnel to administer the vaccines. A heat\u2010stable and highly porous tablet vaccine that can be administered sublingually via simple dissolution under the tongue is described. SIMPL tablet vaccines (Supramolecular IMmunization with Peptides subLingually) are produced by freeze\u2010drying a mixture of self\u2010assembling peptide\u2010polymer nanofibers, sugars, and adjuvant. Sublingual immunization with SIMPL tablets raises antibody responses against both a model epitope from ovalbumin and a clinically relevant epitope from <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. Further, sublingual antibody responses are not diminished after heating the tablets for 1 week at 45 \u00b0C, in contrast to a more conventional carrier vaccine (KLH). This approach directly addresses the need for a heat\u2010stable and easily deliverable vaccine to improve equity in global vaccine coverage.<\/jats:p>","DOI":"10.1002\/adhm.202001614","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:42:52Z","timestamp":1614314572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization"],"prefix":"10.1002","volume":"10","author":[{"given":"Sean H.","family":"Kelly","sequence":"first","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel E.","family":"Opolot","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoying","family":"Wu","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cossette","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K.","family":"Varadhan","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-4827","authenticated-orcid":false,"given":"Joel H.","family":"Collier","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Duke University  Durham NC 27708 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6842a1"},{"key":"e_1_2_6_2_1","volume-title":"Omega","author":"De Boeck K.","year":"2019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.08.045"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.11.099"},{"key":"e_1_2_6_5_1","volume-title":"Vacunas (English Edition)","author":"Reina J.","year":"2019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.060"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01255"},{"key":"e_1_2_6_8_1","author":"Fries C. 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