{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:24:41Z","timestamp":1784899481144,"version":"3.55.0"},"reference-count":148,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102014\u2010StG \u2013 637830"],"award-info":[{"award-number":["ERC\u20102014\u2010StG \u2013 637830"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute viral respiratory tract infections (AVRIs) are a major burden on human health and global economy and amongst the top five causes of death worldwide resulting in an estimated 3.9 million lives lost every year. In addition, new emerging respiratory viruses regularly cause outbreaks such as SARS\u2010CoV\u20101 in 2003, the \"Swine flu\" in 2009, or most importantly the ongoing SARS\u2010CoV\u20102 pandemic, which intensely impact global health, social life, and economy. Despite the prevalence of AVRIs and an urgent need, no vaccines\u2014except for influenza\u2014or effective treatments were available at the beginning of the COVID\u201019 pandemic. However, the innate RNAi pathway offers the ability to develop nucleic acid\u2010based antiviral drugs. siRNA sequences against conserved, essential regions of the viral genome can prevent viral replication. In addition, viral infection can be averted prophylactically by silencing host genes essential for host\u2013viral interactions. Unfortunately, delivering siRNAs to their target cells and intracellular site of action remains the principle hurdle toward their therapeutic use. Currently, siRNA formulations and chemical modifications are evaluated for their delivery. This progress report discusses the selection of antiviral siRNA sequences, delivery techniques to the infection sites, and provides an overview of antiviral siRNAs against respiratory viruses.<\/jats:p>","DOI":"10.1002\/adhm.202001650","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T02:45:37Z","timestamp":1611801937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["siRNA Therapeutics against Respiratory Viral Infections\u2014What Have We Learned for Potential COVID\u201019 Therapies?"],"prefix":"10.1002","volume":"10","author":[{"given":"Aditi","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Pharmacy Pharmaceutical Technology and Biopharmaceutics Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Butenandtstra\u00dfe 5 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Michler","sequence":"additional","affiliation":[{"name":"Institute of Virology Technische Universit\u00e4t M\u00fcnchen  Trogerstr. 30 Munich 81675 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-3916","authenticated-orcid":false,"given":"Olivia M.","family":"Merkel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Pharmaceutical Technology and Biopharmaceutics Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Butenandtstra\u00dfe 5 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"WHO Battle against Respiratory Viruses (BRaVe) Initiative https:\/\/www.who.int\/influenza\/patient_care\/clinical\/brave\/en\/(accessed:2020)."},{"key":"e_1_2_9_2_1","unstructured":"WHO Influenza (seasonal) Factsheet Geneva2016 http:\/\/www.who.int\/mediacentre\/factsheets\/fs211\/en\/(accessed: 19 January2021)."},{"key":"e_1_2_9_3_1","unstructured":"Weekly Epidemiological Record (WER) https:\/\/www.who.int\/wer\/2012\/wer8747\/en\/(accessed: 23 November2012 47 461."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.18527\/2500-2236-2018-5-1-12-21"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.06.005"},{"key":"e_1_2_9_6_1","unstructured":"FDA 2020."},{"key":"e_1_2_9_7_1","unstructured":"New England Journal of Medicine 2020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.05.018"},{"key":"e_1_2_9_9_1","first-page":"24","volume":"103","author":"Selvaraj V.","year":"2020","journal-title":"R. I. Med. J."},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30764-7"},{"key":"e_1_2_9_10_1","author":"Gaebler C.","year":"2021","journal-title":"Nature"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa659"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.01.021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35078107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35888"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.52"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1356"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm828"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1051"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm548"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2004.10.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.38"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0983-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01269-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02288-1"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1279970"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-1-34"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-92-22538"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.009"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200110p"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02989-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.01.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt831"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1081"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.177"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.081"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00694-10"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2299-6"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.031"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(04)00087-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2665"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.180"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1385\/MB:33:2:141"},{"key":"e_1_2_9_39_1","author":"Ambike S.","year":"2020","journal-title":"Res. Square"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.01.012"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01565-06"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-007-0951-z"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.23"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1038"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0034"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06765"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3229"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.3989"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0075-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3078"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020092"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.06.008"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12993"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.131"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375460"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.15.8"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2019-0018"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00036"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00971"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr800409e"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.055"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1164"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402486101"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402630101"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00014-09"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912186107"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0422OC"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609243"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2.4.639"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c15-00615"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.10.009"},{"key":"e_1_2_9_69_1","unstructured":"WHO https:\/\/covid19.who.int\/(accessed: 11 December2020)."},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2003762"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001899"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2286-9"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05985-9"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-8-225"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4166"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.16337"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa015"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01061"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022483"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0400-4"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2008-3"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104260"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2010.11.021"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00440-09"},{"key":"e_1_2_9_86_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-62703-140-0_18","volume":"948","author":"Merkel O. M.","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2742"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.011"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900107v"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6528\/aa6d15"},{"key":"e_1_2_9_89_3","first-page":"A36","volume":"32","author":"d'Angelo I.","year":"2019","journal-title":"J. Aerosol Med. Pulm. Drug Delivery"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.02.017"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.03.029"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00165-13"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0339OC"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.14.1.8534481"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2011.03.027"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81749-0"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc800408g"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903241788"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.03.007"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.223.45"},{"key":"e_1_2_9_99_3","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0363OC"},{"key":"e_1_2_9_99_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2010.11.004"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0602-4"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-020-00272-6"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008"},{"key":"e_1_2_9_103_1","unstructured":"Alnylam Pharmaceuticals https:\/\/investors.alnylam.com\/press-release?id=24656(accessed: 19 January2021)."},{"key":"e_1_2_9_104_1","unstructured":"NS Healthcare https:\/\/www.ns-healthcare.com\/news\/sirnaomics-rnai-2019-ncov\/(accessed: 19 January2021)"},{"key":"e_1_2_9_105_1","unstructured":"BioWorld https:\/\/www.bioworld.com\/articles\/496288-olix-close-to-bringing-covid-19-drug-candidate-to-the-clinic(accessed: 19 January2021)"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-018-1183-0"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2009.35"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0255-y"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.12.040"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200409-046TA"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp8002418"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9685"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6851"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200800922"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.09.005"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016205520044"},{"key":"e_1_2_9_115_2","first-page":"1257","volume":"47","author":"Rau J. L.","year":"2002","journal-title":"Respir. Care"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.08.013"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(00)00339-2"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.06.010"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.09.089"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1634"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118818"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.10.009"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2019.08.012"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1174"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01557-08"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437841100"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.09.005"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1280"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302479"},{"key":"e_1_2_9_130_1","first-page":"EP20201629","author":"Merkel O. M.","year":"2020","journal-title":"Patent Application"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202001650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202001650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202001650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:09:02Z","timestamp":1759763342000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202001650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":148,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/adhm.202001650"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202001650","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]},"assertion":[{"value":"2020-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2001650"}}